TY - JOUR
T1 - Angiogenesis, thrombospondin-1 and cervical carcinogenesis
AU - Wu, Ming Ping
AU - Chou, Cheng Yang
N1 - Funding Information:
This work was supported by a grant from the National Science Council, Taiwan (No. 93-2917-I-006-002).
PY - 2005/6
Y1 - 2005/6
N2 - Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumor development. The process involves interaction among cancer cells, endothelial cells, and components of the extracellular matrix, and is regulated by the balance of angiogenesis activators and angiogenesis inhibitors. This review profiles some fundamental concepts of angiogenesis, the importance of angiogenesis in cervical neoplasm, and the role of thrombospondin-1 as an angiogenesis inhibitor in cervical carcinogenesis. The usefulness and limitations of microvessel density in evaluation of angiogenic status are also discussed. Recent research and evolving concepts have led to a paradigm shift in anticancer therapy, from conventional cancer-centered chemotherapy to angiogenic or "metronomic" chemotherapy and/or combined angiogenesis inhibitors. The epigenetic strategy, which views the tumor system as a whole, transcends the cancer gene-centered approach.
AB - Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumor development. The process involves interaction among cancer cells, endothelial cells, and components of the extracellular matrix, and is regulated by the balance of angiogenesis activators and angiogenesis inhibitors. This review profiles some fundamental concepts of angiogenesis, the importance of angiogenesis in cervical neoplasm, and the role of thrombospondin-1 as an angiogenesis inhibitor in cervical carcinogenesis. The usefulness and limitations of microvessel density in evaluation of angiogenic status are also discussed. Recent research and evolving concepts have led to a paradigm shift in anticancer therapy, from conventional cancer-centered chemotherapy to angiogenic or "metronomic" chemotherapy and/or combined angiogenesis inhibitors. The epigenetic strategy, which views the tumor system as a whole, transcends the cancer gene-centered approach.
KW - Angiogenesis activator
KW - Angiogenesis inhibitor
KW - Cervical cancer
KW - Metronomic chemotherapy
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U2 - 10.1016/S1028-4559(09)60124-8
DO - 10.1016/S1028-4559(09)60124-8
M3 - Review article
AN - SCOPUS:22144455375
SN - 1028-4559
VL - 44
SP - 128
EP - 138
JO - Taiwanese Journal of Obstetrics and Gynecology
JF - Taiwanese Journal of Obstetrics and Gynecology
IS - 2
ER -
