Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Ming Shian Lee, Shih Wei Wang, Guei Jane Wang, Ka Lai Pang, Ching Kuo Lee, Yueh Hsiung Kuo, Hyo Jung Cha, Ruo Kai Lin, Tzong Huei Lee

研究成果: 雜誌貢獻文章同行評審

33 引文 斯高帕斯(Scopus)


Seven new polyketides, phomaketides A-E (1-5) and pseurotins A3 (6) and G (7), along with the known compounds FR-111142, pseurotins A, A1, A2, D, and F2, 14-norpseurotin A, α-carbonylcarbene, tyrosol, cyclo(-l-Pro-l-Leu), and cyclo(-l-Pro-l-Phe), were purified from the fermentation broth and mycelium of the endophytic fungal strain Phoma sp. NTOU4195 isolated from the marine red alga Pterocladiella capillacea. The structures were established through interpretation of spectroscopic data. The antiangiogenic and anti-inflammatory effects of 1-7 and related analogues were evaluated using human endothelial progenitor cells (EPCs) and lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells, respectively. Of the compounds tested, compound 1 exhibited the most potent antiangiogenic activity by suppressing the tube formation of EPCs with an IC50 of 8.1 μM, and compound 3 showed the most selective inhibitory activity of LPS-induced NO production in RAW264.7 macrophages with an IC50 value of 8.8 μM.

頁(從 - 到)2983-2990
期刊Journal of Natural Products
出版狀態已發佈 - 12月 23 2016

ASJC Scopus subject areas

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學


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