Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Chin Hung Liu; Jin Ding Huang; Shi Wei Huang; Tzyh Chyuan Hour; Yung Kai Huang; Yu Mei Hsueh; Hung Yi Chiou; Te Chang Lee; Kun Yan Jan; Chien Jen Chen; Yeong Shiau Pu

doi:10.1007/s11373-007-9215-x

Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Chin Hung Liu, Jin Ding Huang, Shi Wei Huang, Tzyh Chyuan Hour, Yung Kai Huang, Yu Mei Hsueh, Hung Yi Chiou, Te Chang Lee, Kun Yan Jan, Chien Jen Chen, Yeong Shiau Pu

研究成果: 雜誌貢獻 › 文章 › 同行評審

12 引文斯高帕斯（Scopus）

摘要

The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

原文	英語
頁（從 - 到）	261-269
頁數	9
期刊	Journal of Biomedical Science
卷	15
發行號	2
DOIs	https://doi.org/10.1007/s11373-007-9215-x
出版狀態	已發佈 - 3月 2008

ASJC Scopus subject areas

內分泌學、糖尿病和代謝
分子生物學
臨床生物化學
細胞生物學
生物化學（醫學）
藥學（醫學）

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10.1007/s11373-007-9215-x

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title = "Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma",

abstract = "The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (",

keywords = "Bladder neoplasms, Carcinogenesis, Tobacco, Trinucleotide repeats, Urinary tract",

author = "Liu, {Chin Hung} and Huang, {Jin Ding} and Huang, {Shi Wei} and Hour, {Tzyh Chyuan} and Huang, {Yung Kai} and Hsueh, {Yu Mei} and Chiou, {Hung Yi} and Lee, {Te Chang} and Jan, {Kun Yan} and Chen, {Chien Jen} and Pu, {Yeong Shiau}",

note = "Funding Information: This study was supported by grants (91GMP012-3 and 91GMP012-4) from the National Science Council, Executive Yuan, Republic of China.",

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doi = "10.1007/s11373-007-9215-x",

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AU - Liu, Chin Hung

AU - Huang, Jin Ding

AU - Huang, Shi Wei

AU - Hour, Tzyh Chyuan

AU - Huang, Yung Kai

AU - Hsueh, Yu Mei

AU - Chiou, Hung Yi

AU - Lee, Te Chang

AU - Jan, Kun Yan

AU - Chen, Chien Jen

AU - Pu, Yeong Shiau

N1 - Funding Information: This study was supported by grants (91GMP012-3 and 91GMP012-4) from the National Science Council, Executive Yuan, Republic of China.

PY - 2008/3

Y1 - 2008/3

N2 - The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

AB - The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

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KW - Carcinogenesis

KW - Tobacco

KW - Trinucleotide repeats

KW - Urinary tract

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Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

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