Analysis of case-only studies accounting for genotyping error

K. F. Cheng

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)


The case-only design provides one approach to assess possible interactions between genetic and environmental factors. It has been shown that if these factors are conditionally independent, then a case-only analysis is not only valid but also very efficient. However, a drawback of the case-only approach is that its conclusions may be biased by genotyping errors. In this paper, our main aim is to propose a method for analysis of case-only studies when these errors occur. We show that the bias can be adjusted through the use of internal validation data, which are obtained by genotyping some sampled individuals twice. Our analysis is based on a simple and yet highly efficient conditional likelihood approach. Simulation studies considered in this paper confirm that the new method has acceptable performance under genotyping errors.

頁(從 - 到)238-248
期刊Annals of Human Genetics
出版狀態已發佈 - 3月 2007

ASJC Scopus subject areas

  • 遺傳學
  • 遺傳學(臨床)