TY - JOUR
T1 - An overview of the rare parotid gland cancer
AU - Ho, Kimberley
AU - Lin, Helen
AU - Ann, David K.
AU - Chu, Peiguo G.
AU - Yen, Yun
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation, and concurrent therapy regimens are compared. We also present the current development status of novel radiation therapy and targeted therapeutics, focusing on intensity-modulated radiation therapy (IMRT), and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) blockages, which are showing promise for improving parotid gland cancer management.
AB - Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation, and concurrent therapy regimens are compared. We also present the current development status of novel radiation therapy and targeted therapeutics, focusing on intensity-modulated radiation therapy (IMRT), and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) blockages, which are showing promise for improving parotid gland cancer management.
KW - Parotid gland cancer
KW - endosomal sorting complexes required for transport
KW - epidermal growth factor receptor
KW - multi-vesicular bodies
KW - salivary gland cancer
KW - targeted therapeutics
KW - vacuolar protein sorting-associated protein 4B
KW - vascular endothelial growth factor
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U2 - 10.1186/1758-3284-3-40
DO - 10.1186/1758-3284-3-40
M3 - Review article
C2 - 21917153
AN - SCOPUS:80052869608
SN - 1758-3284
VL - 3
JO - Head and Neck Oncology
JF - Head and Neck Oncology
IS - 1
M1 - 40
ER -