摘要
A clinical sorting chip integrated with new protein sensing technique has been developed in this work. Antibody-coated nanobeads reacted with antigen was separated from blood plasma based on dielectrophoresis (DEP) forces. MEMS fabrication process was used to produce the bio-chip and only two photo masks were required in the experiment. By using oxygen-plasma direct bonding method, the assembly of an electrode chip and the microchannels will form a set of RBCs and nanobeads separating chip. The original concentration of antigen can be rapidly estimated by nanobeads' Brownian motion measurement in varies of the viscous solutions. During the antibody-antigen reacting, the mean value of the beads diameter increased so that the Brownian velocity decreased with increasing time. The Brownian motion of nanobeads was observed and measured by micro-particle tracking velocimetry (μ-PTV).
原文 | 英語 |
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主出版物標題 | 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 |
頁面 | 487-491 |
頁數 | 5 |
DOIs | |
出版狀態 | 已發佈 - 2010 |
對外發佈 | 是 |
事件 | 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 - Xiamen, 中国 持續時間: 1月 20 2010 → 1月 23 2010 |
會議
會議 | 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 |
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國家/地區 | 中国 |
城市 | Xiamen |
期間 | 1/20/10 → 1/23/10 |
ASJC Scopus subject areas
- 控制與系統工程
- 電氣與電子工程