An innovative three-dimensional printed titanium implant with a biomimetic structure design for promoting osseointegration potential

Taufik Abdullah Mappa, Shu Fen Chu, Kuo Sheng Hung, Takashi Saito, Muhammad Ruslin, Wen Chien Lan, Hsin Hui Kuo, Yung Chieh Cho, Chia Chien Hsieh, Jonathan Huang, Yung Kang Shen, Keng Liang Ou

研究成果: 雜誌貢獻文章同行評審

摘要

The present study aimed to investigate the surface characteristic, biocompatibility, and bone regeneration behavior of an innovative three-dimensional (3D) printed titanium (Ti) implant with a biomimetic cancellous bone-like spherical particle porous structure (3DBCP-Ti) through scanning electron microscopy, X-ray diffractometry, static contact angle goniometry, cytotoxicity assay, and rabbit model. The analytical results showed that the 3DBCP-Ti implant with an average pore size of 400 ± 10.5 μm can be fabricated using a selective laser sintering method. The 3DBCP-Ti implant not only possessed excellent wettability (13.5 ± 1.7°) but also presented superior cell viability (97 ± 1.5 %) in vitro. After implantation for 4 weeks, the bone mineral density of the 3DBCP-Ti implant (0.14 ± 0.02 mg/cm3) exhibited a slightly higher value than the control implant (0.13 ± 0.03 mg/cm3). Moreover, histological results also indicated that the new bone formation area of the 3DBCP-Ti implant (43.9 ± 7.0 %, *p < 0 0.05) significantly enhanced as compared with the control (23.5 ± 4.6 %) and blank (18.2 ± 1.4 %) groups at week 12 post-implantation. Accordingly, these findings demonstrate that the innovative 3DBCP-Ti implant has the potential to promote osseointegration at early-stage implantation for dental, orthopedic, and neurosurgical applications.
原文英語
文章編號112692
期刊Materials and Design
238
DOIs
出版狀態已發佈 - 2月 2024

ASJC Scopus subject areas

  • 一般材料科學
  • 材料力學
  • 機械工業

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