An innovative bioceramic bone graft substitute for bone defect treatment: In vivo evaluation of bone healing

Syamsiah Syam, Yung Chieh Cho, Chung Ming Liu, Mao Suan Huang, Wen Chien Lan, Bai Hung Huang, Takaaki Ueno, Chi Hsun Tsai, Takashi Saito, May Show Chen, Keng Liang Ou

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)


This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2◦C, and the maximum temperature reached is 31◦C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment.
頁(從 - 到)1-13
期刊Applied Sciences (Switzerland)
出版狀態已發佈 - 11月 2 2020

ASJC Scopus subject areas

  • 一般材料科學
  • 儀器
  • 一般工程
  • 製程化學與技術
  • 電腦科學應用
  • 流體流動和轉移過程


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