An innovative α-calcium sulfate hemihydrate bioceramic as a potential bone graft substitute

Heng Jui Hsu, Rahmat Abd Waris, Muhammad Ruslin, Yun Ho Lin, Chin Sung Chen, Keng Liang Ou

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)


The microstructural, in vitro and in vivo properties of the microwave-synthesized samples were investigated using the optical microscope, scanning electron microscope, X-ray diffraction, differential scanning calorimeter, contact angle goniometer, cell cytotoxicity assay, and chick chorioallantoic membrane (CAM) model in the study. When the calcium sulfate dihydrate (CSD) precursor underwent microwave irradiation treatment at temperatures between 100°C and 160°C, the crystal morphologies and crystalline structures were transformed from (tablet-like CSD (monoclinic)) → (tablet-like CSD (monoclinic) + long column α-calcium sulfate hemihydrate (α-CSH, hexagonal)) → (long column CSD (monoclinic) + short column α-CSH (hexagonal)) → (uniform short column α-CSH (hexagonal)). The high-purity α-CSH with uniform short column crystals around 10 μm in length can be synthesized at 160°C for 10 minutes and exhibits a higher hydrophilic feature in blood. Moreover, the cell cytotoxicity assay indicated that the microwave-synthesized samples possessed well biocompatibility. In vivo results also demonstrated that the microwave-synthesized α-CSH not only induces angiogenesis formation but also facilitates osteogenesis. Therefore, the microwave-synthesized α-CSH is a promising bone graft substitute that can be applied in dental and orthopedic fields.
頁(從 - 到)419-427
期刊Journal of the American Ceramic Society
出版狀態已發佈 - 2018

ASJC Scopus subject areas

  • 陶瓷和複合材料
  • 材料化學


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