Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures

Syu Jyun Peng, Yue Loong Hsin

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)


Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI) to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls. All the patients were medically effective and MRI-negative. Using whole brain voxel-based morphometry (VBM) to compare the patients with the normal controls, we observed significantly decreased gray matter (GM) density in the thalamus and 3 frontal gyri and significantly reduced white matter (WM) fractional anisotropy (FA) in the bilateral anterior corona radiata of the patients. Alterations in the thalamocortical functional connectivity with different cortices were identified by the rs-fMRI analysis seeding of the whole thalamus. The prefrontal gyri with the greatest functional connectivity were also traced by seeding a sub-thalamic region that is demarcated in an atlas, in which the thalamic parcellation is based on the WM connectivity to the cortices. This sub-thalamic region anatomically contains the mediodorsal thalamic nucleus where, concordantly, there was a significant decrease in thalamic GM density in the VBM study. In contrast to the negative correlation between the disease duration and reduced thalamic densities and subcortical FA values, the strength of the functional thalamocortical connectivity had a paradoxical correlation. Our results conclusively indicate that generalized seizures with a focal cortical source are associated with structural and functional alterations in the thalamocortical network.
頁(從 - 到)55-61
期刊NeuroImage: Clinical
出版狀態已發佈 - 1月 1 2017

ASJC Scopus subject areas

  • 放射學、核子醫學和影像學
  • 神經內科
  • 神經病學(臨床)
  • 認知神經科學


深入研究「Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures」主題。共同形成了獨特的指紋。