TY - JOUR
T1 - Alkylphenols - Potential modulators of the allergic response
AU - Suen, Jau Ling
AU - Hung, Chih Hsin
AU - Yu, Hsin Su
AU - Huang, Shau Ku
PY - 2012/7
Y1 - 2012/7
N2 - The prevalence of allergic diseases has increased in recent decades. Allergic diseases, particularly asthma, are complex diseases with strong gene-environment interactions. Epidemiological studies have identified a variety of risk factors for the development of allergic diseases. Among them, endocrine-disrupting chemicals (EDCs) play an important role in triggering or exacerbating these diseases. 4-Nonylphenol (NP) and 4-octylphenol (OP) - two major alkylphenols - have been recognized as common toxic and xenobiotic endocrine disrupters. Due to their low solubility, high hydrophobicity, and low estrogenic activity, they tend to accumulate in the human body and may be associated with the adverse effects of allergic diseases. Recently, new evidence has supported the importance of alkylphenols in the in vitro allergic response. This review focuses on the effects of alkylphenols on several key cell types in the context of allergic inflammation.
AB - The prevalence of allergic diseases has increased in recent decades. Allergic diseases, particularly asthma, are complex diseases with strong gene-environment interactions. Epidemiological studies have identified a variety of risk factors for the development of allergic diseases. Among them, endocrine-disrupting chemicals (EDCs) play an important role in triggering or exacerbating these diseases. 4-Nonylphenol (NP) and 4-octylphenol (OP) - two major alkylphenols - have been recognized as common toxic and xenobiotic endocrine disrupters. Due to their low solubility, high hydrophobicity, and low estrogenic activity, they tend to accumulate in the human body and may be associated with the adverse effects of allergic diseases. Recently, new evidence has supported the importance of alkylphenols in the in vitro allergic response. This review focuses on the effects of alkylphenols on several key cell types in the context of allergic inflammation.
KW - 4-nonylphenol
KW - 4-octylphenol
KW - Allergic inflammation
KW - Endocrine-disrupting chemical
UR - http://www.scopus.com/inward/record.url?scp=84864608840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864608840&partnerID=8YFLogxK
U2 - 10.1016/j.kjms.2012.05.009
DO - 10.1016/j.kjms.2012.05.009
M3 - Article
C2 - 22871601
AN - SCOPUS:84864608840
SN - 1607-551X
VL - 28
SP - S43-S48
JO - Kaohsiung Journal of Medical Sciences
JF - Kaohsiung Journal of Medical Sciences
IS - 7 SUPPL.
ER -
