TY - JOUR
T1 - Aging modulates dispersion of ventricular repolarization in the very old of the geriatric population
AU - Huang, Jen Hung
AU - Lin, Ying Chin
AU - Pan, Nan Hung
AU - Chen, Yi Jen
N1 - Funding Information:
This work was supported by the Center of Excellence for Clinical Trial and Research in Neuroscience (DOH99-TD-B-111-003) and grants NSC 96-2628-B-038-012-MY3, NSC 96-2314-B-010-006, NSC 97-2314-B-038-030-MY3.
PY - 2010/11
Y1 - 2010/11
N2 - Aging plays an essential role in cardiac pathophysiology. Knowledge on the ventricular repolarization in very old individuals is limited. An increase of QT dispersion is associated with higher cardiovascular mortality. The purpose of this study is to investigate whether aging changes the QT dispersion in the very old. Heart rate, P wave duration, PR interval, QRS axis, QRS duration, QT interval, and QTc interval were measured from 12-lead resting ECG. QT dispersion (46 ± 21, 47 ± 17, 69 ± 31 ms, p < 0.005) was significantly increased in the age group 85 years (n = 29, 89 ± 4 years) than in the age group 75-84 years (n = 33, 79 ± 3 years) and the age group 65-74 years (n = 32, 68 ± 3 years). Aging modulates dispersion of ventricular repolarization, which may contribute to the cardiac mortality in the very old Asian population.
AB - Aging plays an essential role in cardiac pathophysiology. Knowledge on the ventricular repolarization in very old individuals is limited. An increase of QT dispersion is associated with higher cardiovascular mortality. The purpose of this study is to investigate whether aging changes the QT dispersion in the very old. Heart rate, P wave duration, PR interval, QRS axis, QRS duration, QT interval, and QTc interval were measured from 12-lead resting ECG. QT dispersion (46 ± 21, 47 ± 17, 69 ± 31 ms, p < 0.005) was significantly increased in the age group 85 years (n = 29, 89 ± 4 years) than in the age group 75-84 years (n = 33, 79 ± 3 years) and the age group 65-74 years (n = 32, 68 ± 3 years). Aging modulates dispersion of ventricular repolarization, which may contribute to the cardiac mortality in the very old Asian population.
KW - Aging
KW - Hypertension
KW - QT dispersion
KW - QTc dispersion
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U2 - 10.1007/s00380-010-0026-z
DO - 10.1007/s00380-010-0026-z
M3 - Article
C2 - 20936293
AN - SCOPUS:78549246719
SN - 0910-8327
VL - 25
SP - 500
EP - 508
JO - Heart and Vessels
JF - Heart and Vessels
IS - 6
ER -