Adolescent Tri-ponderal Mass Index Growth Trajectories and Incident Diabetes Mellitus in Early Adulthood

Yi-Fan Wu, Hsien-Yu Fan, Yang-Ching Chen, Kuan-Liang Kuo, Kuo-Liong Chien

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)


PURPOSE: Studies have reported the influence of adolescent obesity on development of adult diabetes, but the effect of the growth pattern during this period has rarely been explored. Also, the tri-ponderal mass index (TMI) was thought to be a better estimation of adolescent body fat levels than the body mass index (BMI), so we sought to investigate whether growth trajectories derived by these two indices could predict incident diabetes.

METHODS: We conducted a study by using the Taipei City Hospital Radiation Building Database, a longitudinal cohort established from 1996 until now. Physical exam results including blood test results were collected annually and the BMI z-score/TMI growth trajectory groups during 13-18 years of age were identified using growth mixture modeling. A Cox proportional hazard model for incident diabetes was used to examine the risk of baseline obese status and different BMI/TMI growth trajectories.

RESULTS: Five growth trajectory groups were identified for the BMI z-score and the TMI. During approximately 20,400 person-years follow-up, 33 of 1,387 participants developed diabetes. Baseline obesity defined by the BMI z-score and the TMI were both related to adult diabetes. The persistent increase TMI growth trajectory exhibited a significantly increased risk of diabetes after adjusting for baseline obese status and other correlated covariates (hazard ratio: 2.85, 95% confidence interval (CI): 1.01-8.09). There was no association between BMI growth trajectory groups and incident diabetes.

CONCLUSIONS: A specific TMI growth trajectory pattern during adolescence might be critical for diabetes prevention efforts.
頁(從 - 到)E2919-E2927
期刊The Journal of clinical endocrinology and metabolism
早期上線日期4月 11 2021
出版狀態已發佈 - 8月 1 2021

ASJC Scopus subject areas

  • 生物化學(醫學)
  • 內分泌
  • 生物化學
  • 臨床生物化學
  • 內分泌學、糖尿病和代謝


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