摘要
Background: Traffic of potentially harmful cytosolic messengers through gap junctions might cause increased injury during ischemia. The present study was to determine whether the infarct size-reducing effect of adjunctive estradiol administration prior to reperfusion is associated with an attenuated expression of connexin43 at the border of infarction in a canine model. Methods: Experiments were performed in 48 dogs (n=16 each group), assigned to receive either vehicle (control group), 17β-estradiol administered before coronary occlusion (early group), or 3 min before coronary reperfusion following 60-min ischemia (late group). Changes in the amount of phosphorylated connexin43 were measured by Western blot. Results: Infarct size was significantly larger in the control (38±7% of area at risk) than in the supplemented groups (16±6% in the early group; 16±8% in the late group, P
原文 | 英語 |
---|---|
頁(從 - 到) | 109-117 |
頁數 | 9 |
期刊 | Cardiovascular Research |
卷 | 63 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 7月 1 2004 |
ASJC Scopus subject areas
- 心臟病學與心血管醫學
- 生理學(醫學)
- 生理學