TY - JOUR
T1 - Adenocarcinoma combined with malignant peripheral nerve sheath tumor of the gallbladder
AU - Chang, Bao Chiien
AU - Tsao, Tang Yi
AU - Hwu, Tsiu Ming
AU - Cheng, Jui Kai
AU - Lee, Wei Hwa
PY - 1997/7
Y1 - 1997/7
N2 - Adenocarcinoma of the gallbladder combined with a malignant peripheral nerve sheath tumor (MPNST) in the gallbladder in an 81-year-old woman is reported. The resected gallbladder showed two distinct tumor components, the epithelioid type of MPNST and adenocarcinoma with areas of mucin production. Although the immediate postoperative course was uneventful, a pathologic fracture of her right upper femur developed 4 months after the cholecystectomy. The pathology was determined to be a feature of metastatic MPNST rather than of adenocarcinoma. A whole body bone scan revealed multiple metastases, including the left parietal skull, left ninth rib, seventh thoracic vertebra, and right upper third of the femur. Despite cholecystectomy and postoperative irradiation therapy, she died 6 months after diagnosis of the tumor. Without an autopsy the primary site of the MPNST was unknown. We found that the prognosis was very poor in patients with distal metastatic MPNST, especially in older patients.
AB - Adenocarcinoma of the gallbladder combined with a malignant peripheral nerve sheath tumor (MPNST) in the gallbladder in an 81-year-old woman is reported. The resected gallbladder showed two distinct tumor components, the epithelioid type of MPNST and adenocarcinoma with areas of mucin production. Although the immediate postoperative course was uneventful, a pathologic fracture of her right upper femur developed 4 months after the cholecystectomy. The pathology was determined to be a feature of metastatic MPNST rather than of adenocarcinoma. A whole body bone scan revealed multiple metastases, including the left parietal skull, left ninth rib, seventh thoracic vertebra, and right upper third of the femur. Despite cholecystectomy and postoperative irradiation therapy, she died 6 months after diagnosis of the tumor. Without an autopsy the primary site of the MPNST was unknown. We found that the prognosis was very poor in patients with distal metastatic MPNST, especially in older patients.
KW - adenocarcinoma
KW - gallbladder neoplasm
KW - malignant peripheral nerve sheath tumor
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M3 - Article
C2 - 9262060
AN - SCOPUS:0030849986
SN - 0929-6646
VL - 96
SP - 545
EP - 548
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 7
ER -