Acute effects of dietary phosphorus intake on markers of mineral metabolism in hemodialysis patients: post hoc analysis of a randomized crossover trial

Wan Chuan Tsai, Hon Yen Wu, Yen Ling Chiu, Ju Yeh Yang, Mei Fen Pai, Yong Ru Wu, Wan Yu Lin, Kuan Yu Hung, Kuo Liong Chien, Shih Ping Hsu, Yu Sen Peng

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Background: Long-term dietary phosphorus excess influences disturbances in mineral metabolism, but it is unclear how rapidly the mineral metabolism responds to short-term dietary change in dialysis populations. Methods: This was a post hoc analysis of a randomized crossover trial that evaluated the short-term effects of low-phosphorus diets on mineral parameters in hemodialysis patients. Within a 9-day period, we obtained a total of 4 repeated measurements for each participant regarding dietary intake parameters, including calorie, phosphorus, and calcium intake, and markers of mineral metabolism, including phosphate, calcium, intact parathyroid hormone (iPTH), intact fibroblast growth factor 23 (iFGF23), and C-terminal fibroblast growth factor 23 (cFGF23). The correlations between dietary phosphorus intake and serum mineral parameters were assessed by using mixed-effects models. Results: Thirty-four patients were analyzed. In the fully adjusted model, we found that an increase in dietary phosphorus intake of 100 mg was associated with an increase in serum phosphate of 0.3 mg/dL (95% confidence intervals [CI], 0.2–0.4, p <.001), a decrease in serum calcium of 0.06 mg/dL (95% CI, −0.11 to −0.01, p =.01), an increase in iPTH of 5.4% (95% CI, 1.4–9.3, p =.01), and an increase in iFGF23 of 5.0% (95% CI, 2.0–8.0, p =.001). Dietary phosphorus intake was not related to cFGF23. Conclusions: Increased dietary phosphorus intake acutely increases serum phosphate, iPTH, and iFGF23 levels and decreases serum calcium levels, highlighting the important role of daily fluctuations of dietary habits in disturbed mineral homeostasis in hemodialysis patients.
原文英語
頁(從 - 到)141-148
頁數8
期刊Renal Failure
43
發行號1
DOIs
出版狀態已發佈 - 2021
對外發佈

ASJC Scopus subject areas

  • 重症監護和重症監護醫學
  • 腎臟病學

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