Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Ting Ting Yang; Cheng Kuei Chang; Chiung Wen Tsao; Ya Mei Hsu; Chao Tien Hsu; Juei Tang Cheng

doi:10.1016/j.neulet.2008.12.029

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Ting Ting Yang
, Cheng Kuei Chang
, Chiung Wen Tsao
, Ya Mei Hsu
, Chao Tien Hsu
, Juei Tang Cheng

研究成果: 雜誌貢獻 › 文章 › 同行評審

29 引文斯高帕斯（Scopus）

摘要

Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

原文	英語
頁（從 - 到）	57-59
頁數	3
期刊	Neuroscience Letters
卷	451
發行號	1
DOIs	https://doi.org/10.1016/j.neulet.2008.12.029
出版狀態	已發佈 - 2月 13 2009
對外發佈	是

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 良好的健康和福祉

ASJC Scopus subject areas

一般神經科學

存取文件

10.1016/j.neulet.2008.12.029

其它文件與鏈接

Link to publication in Scopus

引用此

@article{1470a6ee197a4f42be4654489c84f1c6,

title = "Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats",

abstract = "Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.",

keywords = "Acetylcholine, Adipose, Glucose uptake, Lipolysis, Muscarinic receptor",

author = "Yang, \{Ting Ting\} and Chang, \{Cheng Kuei\} and Tsao, \{Chiung Wen\} and Hsu, \{Ya Mei\} and Hsu, \{Chao Tien\} and Cheng, \{Juei Tang\}",

year = "2009",

month = feb,

day = "13",

doi = "10.1016/j.neulet.2008.12.029",

language = "English",

volume = "451",

pages = "57--59",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

AU - Yang, Ting Ting

AU - Chang, Cheng Kuei

AU - Tsao, Chiung Wen

AU - Hsu, Ya Mei

AU - Hsu, Chao Tien

AU - Cheng, Juei Tang

PY - 2009/2/13

Y1 - 2009/2/13

N2 - Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

AB - Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

KW - Acetylcholine

KW - Adipose

KW - Glucose uptake

KW - Lipolysis

KW - Muscarinic receptor

UR - https://www.scopus.com/pages/publications/58649123092

UR - https://www.scopus.com/pages/publications/58649123092#tab=citedBy

U2 - 10.1016/j.neulet.2008.12.029

DO - 10.1016/j.neulet.2008.12.029

M3 - Article

C2 - 19111904

AN - SCOPUS:58649123092

SN - 0304-3940

VL - 451

SP - 57

EP - 59

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

摘要

UN SDG

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

引用此