Action of Reverse T3 on Cancer Cells

Hung Yun Lin; Heng Yuan Tang; Matthew Leinung; Shaker A. Mousa; Aleck Hercbergs; Paul J. Davis

doi:10.1080/07435800.2019.1600536

Action of Reverse T3 on Cancer Cells

Hung Yun Lin, Heng Yuan Tang, Matthew Leinung, Shaker A. Mousa, Aleck Hercbergs, Paul J. Davis

研究成果: 雜誌貢獻 › 文章 › 同行評審

20 引文斯高帕斯（Scopus）

摘要

Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.

原文	英語
頁（從 - 到）	148-152
頁數	5
期刊	Endocrine Research
卷	44
發行號	4
DOIs	https://doi.org/10.1080/07435800.2019.1600536
出版狀態	已發佈 - 1月 1 2019

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title = "Action of Reverse T3 on Cancer Cells",

abstract = "Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.",

keywords = "3,3',5{\textquoteright}-triiodo-L-thyronine, breast cancer, glioblastoma, Integrin αvβ3, L-thyroxine",

author = "Lin, {Hung Yun} and Tang, {Heng Yuan} and Matthew Leinung and Mousa, {Shaker A.} and Aleck Hercbergs and Davis, {Paul J.}",

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AU - Lin, Hung Yun

AU - Tang, Heng Yuan

AU - Leinung, Matthew

AU - Mousa, Shaker A.

AU - Hercbergs, Aleck

AU - Davis, Paul J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.

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KW - glioblastoma

KW - Integrin αvβ3

KW - L-thyroxine

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Action of Reverse T3 on Cancer Cells

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