摘要
Appropriate treatment is the key element in eliminating tuberculosis (TB), and requires prompt diagnosis. We presented a case of a household contact of rifampicin-resistant TB revealing reactive IFN-gamma release assay with unsuspicious clinical and radiologic examinations. She was diagnosed with latent tuberculosis infection (LTBI) and treated with isoniazid monotherapy. On the ninth month, she developed a progressive cough and was found to harbor active TB disease with added resistance to isoniazid. An individualized anti-TB regimen consisting of moxifloxacin, kanamycin, prothionamide, ethambutol, and pyr-azinamide was prescribed for 20 months, leading to sputum culture conversion and improve-ment of the reported symptom. No recurrence was observed on one-year follow-up. Assuming high compliance to therapy, we propose that the patient may have been under-diagnosed and received sub-optimal treatment leading to acquired-drug resistance. Conventional diagnosis methods based on immunological assay and radiographical findings may be insufficient to distinguish the incipient and subclinical states of TB from LTBI.
原文 | 英語 |
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頁(從 - 到) | 1505-1509 |
頁數 | 5 |
期刊 | Infection and Drug Resistance |
卷 | 14 |
DOIs | |
出版狀態 | 已發佈 - 2021 |
ASJC Scopus subject areas
- 藥理
- 傳染性疾病
- 藥學(醫學)