A viral kinase mimics S6 kinase to enhance cell proliferation

Aadra Prashant Bhatt, Jason P. Wong, Marc S. Weinberg, Kurtis M. Host, Louise C. Giffin, Joshua Buijnink, Evert Van Dijk, Yoshihiro Izumiya, Hsing Jien Kung, Brenda R.S. Temple, Blossom Damania

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25 引文 斯高帕斯(Scopus)


Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi's sarcoma-associated herpesvirus (KSHV) enhances protein synthesis by mimicking the function of the cellular protein S6 kinase (S6KB1). Similar to S6KB1, vPK phosphorylates the ribosomal S6 protein and up-regulates global protein synthesis. vPK also augments cellular proliferation and anchorage-independent growth. Furthermore, we report that both vPK and S6KB1 phosphorylate the enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) and that both kinases promote endothelial capillary tubule formation.
頁(從 - 到)7876-7881
期刊Proceedings of the National Academy of Sciences of the United States of America
出版狀態已發佈 - 7月 12 2016

ASJC Scopus subject areas

  • 多學科


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