TY - JOUR
T1 - A Structured–Activity Relationship Study of Batracylin Analogues
AU - Luo, Yilin
AU - Ren, Yun Feng
AU - Chou, Ting Chao
AU - Chen, Allan Y.
AU - Yu, Chiang
AU - Liu, Leroy F.
AU - Cheng, C. C.
PY - 1993/6
Y1 - 1993/6
N2 - A number of isoindolo[l ,2- b]quinazolines and some benzo[4,5]isoquinolino[l,2- b]quinazolines as structural modification analogues of the antitumor compound batracylin were synthesized and evaluated against HL-60 cell growth and in topoisomerase II-mediated DNA cleavage assays. Of the compounds studied, 10,12-dihydro-7,8-methy lenedioxyisoindolo[ 1,2- b] quinazolin-12(10 H)-one 1d, 2-amino-10,12-dihydroisoindolo[l ,2- b]quinazolin- 12(10 H)-one 1p, and 2-amino-7,8-methylenedioxy-10,12-dihydroisoindolo[l ,2- b]quinazolin-12(10 H)-one 1ab exhibited good inhibitory activities against HL-60 cell lines as well as induction of topo II-mediated DNA cleavage activities.
AB - A number of isoindolo[l ,2- b]quinazolines and some benzo[4,5]isoquinolino[l,2- b]quinazolines as structural modification analogues of the antitumor compound batracylin were synthesized and evaluated against HL-60 cell growth and in topoisomerase II-mediated DNA cleavage assays. Of the compounds studied, 10,12-dihydro-7,8-methy lenedioxyisoindolo[ 1,2- b] quinazolin-12(10 H)-one 1d, 2-amino-10,12-dihydroisoindolo[l ,2- b]quinazolin- 12(10 H)-one 1p, and 2-amino-7,8-methylenedioxy-10,12-dihydroisoindolo[l ,2- b]quinazolin-12(10 H)-one 1ab exhibited good inhibitory activities against HL-60 cell lines as well as induction of topo II-mediated DNA cleavage activities.
KW - DNA topoisomerase
KW - colon adenocarcinoma 38
KW - cytotoxicity
KW - isoindolo[l,2- b]quinazolines
KW - structure–activity relationship
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U2 - 10.1023/A:1018929815422
DO - 10.1023/A:1018929815422
M3 - Article
C2 - 8391697
AN - SCOPUS:0027322883
SN - 0724-8741
VL - 10
SP - 918
EP - 923
JO - Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
JF - Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
IS - 6
ER -