TY - JOUR
T1 - A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease
AU - Kuo, Ho-Chang
AU - Hsu, Yu-Wen
AU - Wu, Chung-Min
AU - Chen, Shawn Hsiang-Yin
AU - Hung, Kuo Sheng
AU - Chang, Wei-Pin
AU - Yang, Kuender D.
AU - Hsieh, Kai-Sheng
AU - Chen, Wei-Chiao
AU - Onouchi, Yoshihiro
AU - Chang, Wei Chiao
PY - 2013/7/24
Y1 - 2013/7/24
N2 - Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.
AB - Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.
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U2 - 10.1371/journal.pone.0069685
DO - 10.1371/journal.pone.0069685
M3 - Article
C2 - 23894522
AN - SCOPUS:84880826298
SN - 1932-6203
VL - 8
JO - PLoS One
JF - PLoS One
IS - 7
M1 - e69685
ER -