A potent virus-specific antibody-secreting cell response to acute enterovirus 71 infection in children

Kuan Ying Arthur Huang, Jainn Jim Lin, Cheng Hsun Chiu, Shuan Yang, Kuo Chien Tsao, Yhu Chering Huang, Tzou Yien Lin

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)


Background: Enterovirus 71 (EV71) remains a leading pathogen for acute infectious diseases in children, especially in Asia. The cellular basis for establishing a virus-specific antibody response to acute EV71 infections is unclear in children. Methods: We studied the magnitude of virus-specific antibody-secreting B cells (ASCs) and its relationship with serological response, clinical parameters, and virological parameters among children with laboratory-confirmed EV71 infection. Results: A potent EV71 genogroup B-and virus-specific ASC response was detected in the first week of illness among genotype B5 EV71-infected children. The cross-reactive EV71-specific ASC response to genogroup C viral antigens composed about 10% of the response. The EV71-specific ASC response in children aged ≥3 years produced immunoglobulin G predominantly, but immunoglobulin M was predominant in younger children. Proliferation marker was expressed by themajority of circulating ASCs in the acute phase of EV71 infection. Virus-specific ASC-responses significantly correlated with throat viral load, fever duration, and serological genogroup-specific neutralization titer. Conclusions: The presence of a virus-specific ASC response serves an early cellular marker of an EV71-specific antibody response. Further detailed study of EV71-specific ASCs at the monoclonal level is crucial to delineate the specificity and function of antibody immunity in children.
頁(從 - 到)808-817
期刊Journal of Infectious Diseases
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • 免疫學和過敏
  • 傳染性疾病


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