A positive association between homeostasis model assessment of insulin resistance score and the Trp64Arg Polymorphism of the β3-adrenergic receptor gene in schizophrenia patients in Taiwan

Hsien Jane Chiu, Ming Yih Lee, Tzuo Yun Lan, El Wui Loh, Jau Tay Wang, Tsuo Hung Lan

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Objective: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan. Method: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance. Results: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P=.033). Conclusions: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.
原文英語
頁(從 - 到)e1-e5
期刊Primary Care Companion to the Journal of Clinical Psychiatry
12
發行號4
DOIs
出版狀態已發佈 - 2010
對外發佈

ASJC Scopus subject areas

  • 精神病學和心理健康

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