TY - JOUR
T1 - A novel resorbable α-calcium sulfate hemihydrate/amorphous calcium phosphate bone substitute for dental implantation surgery
AU - Wu, Hong Da
AU - Lee, Sheng Yang
AU - Poma, Malosi
AU - Wu, Jia Yo
AU - Wang, Duen Cheng
AU - Yang, Jen Chang
PY - 2012/4/1
Y1 - 2012/4/1
N2 - The purpose of this study was to prepare resorbable α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP) bone substitute with a resorption period of 3-6 months specifically designed for dental implantation surgery. A one-pot process was used to manufacture α-CSH and ACP. Granular particles of α-CSH/ACP (60/40) with diameters of 420-840 μm were prepared. In dissolution test, both α-CSH/ACP (60/40) and CSD displayed rapid dissolution in the first 20 days, followed by a remarkably slow dissolution rate to reach weight retention plateaus of around 13.5%±0.7% and 40.5%±1.4% at 90 days, respectively. The in vivo study showed no adverse effects as a consequence of any of the implanted materials. After 3 weeks, the defects treated with α-CSH/ACP (60/40) showed more new bone formation (21.1%) than the empty control (13.6%) (p
AB - The purpose of this study was to prepare resorbable α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP) bone substitute with a resorption period of 3-6 months specifically designed for dental implantation surgery. A one-pot process was used to manufacture α-CSH and ACP. Granular particles of α-CSH/ACP (60/40) with diameters of 420-840 μm were prepared. In dissolution test, both α-CSH/ACP (60/40) and CSD displayed rapid dissolution in the first 20 days, followed by a remarkably slow dissolution rate to reach weight retention plateaus of around 13.5%±0.7% and 40.5%±1.4% at 90 days, respectively. The in vivo study showed no adverse effects as a consequence of any of the implanted materials. After 3 weeks, the defects treated with α-CSH/ACP (60/40) showed more new bone formation (21.1%) than the empty control (13.6%) (p
KW - Amorphous calcium phosphate
KW - Bone graft substitute
KW - Dental implant surgery
KW - Resorption rate
KW - α-calcium sulfate hemihydrate
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U2 - 10.1016/j.msec.2011.11.016
DO - 10.1016/j.msec.2011.11.016
M3 - Article
AN - SCOPUS:84865740398
SN - 0928-4931
VL - 32
SP - 440
EP - 446
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
IS - 3
ER -