摘要
The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.
原文 | 英語 |
---|---|
頁(從 - 到) | 63-64 |
頁數 | 2 |
期刊 | Acta Anaesthesiologica Taiwanica |
卷 | 45 |
發行號 | 2 |
出版狀態 | 已發佈 - 6月 2007 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 麻醉與疼痛醫學
- 醫藥 (全部)