A novel mechanism involved in TLR4 expression during inflammation

Chi Yuan Li; Feng Yen Lin

A novel mechanism involved in TLR4 expression during inflammation

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

The p47^phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

原文	英語
頁（從 - 到）	63-64
頁數	2
期刊	Acta Anaesthesiologica Taiwanica
卷	45
發行號	2
出版狀態	已發佈 - 6月 2007
對外發佈	是

ASJC Scopus subject areas

麻醉與疼痛醫學
醫藥 (全部)

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abstract = "The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.",

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AB - The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

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A novel mechanism involved in TLR4 expression during inflammation

摘要

ASJC Scopus subject areas

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