A new angular naphthopyrone from feather star Comanthus parvicirrus (Müller, 1841)

Zong You Ke; Jun Wen Chen; Bo Yan Wu; Yi Yan Jhan; Zhi Hong Wen; Te An Kung; Ping Jyun Sung; Jih Jung Chen; Kuei Hung Lai; Hsu Ming Chung

doi:10.1016/j.molstruc.2021.132261

A new angular naphthopyrone from feather star Comanthus parvicirrus (Müller, 1841)

Zong You Ke
, Jun Wen Chen
, Bo Yan Wu
, Yi Yan Jhan
, Zhi Hong Wen
, Te An Kung
, Ping Jyun Sung
, Jih Jung Chen
, Kuei Hung Lai
, Hsu Ming Chung

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

摘要

A chemical investigation was carried out on a feather star Comanthus parvicirrus collected from the waters of Southern Taiwan, which led to the isolation of three angular naphthopyrones (1–3), including one new metabolite, 8‑hydroxy-5,6,9,10-tetramethoxy-2-methyl-4H-benzo[h]chromen-4-one (1). The structures of compounds 1–3 were assigned based on spectroscopic methods, including UV, MS, 1D- and 2D-NMR spectra, and the structure of 1 was established by single-crystal X-ray diffraction analysis directly. The compound 3 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

原文	英語
文章編號	132261
期刊	Journal of Molecular Structure
卷	1253
DOIs	https://doi.org/10.1016/j.molstruc.2021.132261
出版狀態	已發佈 - 4月 5 2022

ASJC Scopus subject areas

分析化學
光譜
有機化學
無機化學

存取文件

10.1016/j.molstruc.2021.132261

其它文件與鏈接

Link to publication in Scopus

CCDC 2117795: Experimental Crystal Structure Determination
Ke, Z.-Y. (Contributor), Chen, J.-W. (Contributor), Wu, B.-Y. (Contributor), Jhan, Y.-Y. (Contributor), Wen, Z.-H. (Contributor), Kung, T.-A. (Contributor), Sung, P.-J. (Contributor), Chen, J.-J. (Contributor), Lai, K.-H. (Contributor) & Chung, H.-M. (Contributor), Cambridge Crystallographic Data Centre, 2022
DOI: 10.5517/ccdc.csd.cc292qz3, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc292qz3&sid=DataCite
資料集: Dataset

引用此

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title = "A new angular naphthopyrone from feather star Comanthus parvicirrus (M{\"u}ller, 1841)",

abstract = "A chemical investigation was carried out on a feather star Comanthus parvicirrus collected from the waters of Southern Taiwan, which led to the isolation of three angular naphthopyrones (1–3), including one new metabolite, 8‑hydroxy-5,6,9,10-tetramethoxy-2-methyl-4H-benzo[h]chromen-4-one (1). The structures of compounds 1–3 were assigned based on spectroscopic methods, including UV, MS, 1D- and 2D-NMR spectra, and the structure of 1 was established by single-crystal X-ray diffraction analysis directly. The compound 3 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.",

keywords = "Comanthus parvicirrus, Crinoid, Feather star, iNOS, Naphthopyrone, X-ray",

author = "Ke, \{Zong You\} and Chen, \{Jun Wen\} and Wu, \{Bo Yan\} and Jhan, \{Yi Yan\} and Wen, \{Zhi Hong\} and Kung, \{Te An\} and Sung, \{Ping Jyun\} and Chen, \{Jih Jung\} and Lai, \{Kuei Hung\} and Chung, \{Hsu Ming\}",

note = "Funding Information: This research was supported by the grants from the National Pingtung University and the Ministry of Science and Technology, Taiwan (Grant Nos: MOST 110-2320-B-153-001) awarded to Hsu-Ming Chung; by the grant from the Ministry of Science and Technology (MOST 110-2320-B-038-034), Ministry of Education (DP2-110-21121-01-N-12-03), and Taipei Medical University (TMU109-AE1-B15) awarded to Kuei-Hung Lai. The authors are thankful the High Valued Instrument Center, National Sun Yat-sen University, for the mass (MS000600) and NMR (NMR001100) Spectra (MOST 110-2731-M-110-001); and to the Instrumentation Center, National Taiwan University for providing X-ray facilities (MOST 110–2731-M-002–001, XRD000200). Funding Information: This research was supported by the grants from the National Pingtung University and the Ministry of Science and Technology, Taiwan (Grant Nos: MOST 110-2320-B-153-001) awarded to Hsu-Ming Chung; by the grant from the Ministry of Science and Technology (MOST 110-2320-B-038-034), Ministry of Education (DP2-110-21121-01-N-12-03), and Taipei Medical University (TMU109-AE1-B15) awarded to Kuei-Hung Lai. The authors are thankful the High Valued Instrument Center, National Sun Yat-sen University, for the mass (MS000600) and NMR (NMR001100) Spectra (MOST 110-2731-M-110-001); and to the Instrumentation Center, National Taiwan University for providing X-ray facilities (MOST 110?2731-M-002?001, XRD000200). Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2022",

month = apr,

day = "5",

doi = "10.1016/j.molstruc.2021.132261",

language = "English",

volume = "1253",

journal = "Journal of Molecular Structure",

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T1 - A new angular naphthopyrone from feather star Comanthus parvicirrus (Müller, 1841)

AU - Ke, Zong You

AU - Chen, Jun Wen

AU - Wu, Bo Yan

AU - Jhan, Yi Yan

AU - Wen, Zhi Hong

AU - Kung, Te An

AU - Sung, Ping Jyun

AU - Chen, Jih Jung

AU - Lai, Kuei Hung

AU - Chung, Hsu Ming

N1 - Funding Information: This research was supported by the grants from the National Pingtung University and the Ministry of Science and Technology, Taiwan (Grant Nos: MOST 110-2320-B-153-001) awarded to Hsu-Ming Chung; by the grant from the Ministry of Science and Technology (MOST 110-2320-B-038-034), Ministry of Education (DP2-110-21121-01-N-12-03), and Taipei Medical University (TMU109-AE1-B15) awarded to Kuei-Hung Lai. The authors are thankful the High Valued Instrument Center, National Sun Yat-sen University, for the mass (MS000600) and NMR (NMR001100) Spectra (MOST 110-2731-M-110-001); and to the Instrumentation Center, National Taiwan University for providing X-ray facilities (MOST 110–2731-M-002–001, XRD000200). Funding Information: This research was supported by the grants from the National Pingtung University and the Ministry of Science and Technology, Taiwan (Grant Nos: MOST 110-2320-B-153-001) awarded to Hsu-Ming Chung; by the grant from the Ministry of Science and Technology (MOST 110-2320-B-038-034), Ministry of Education (DP2-110-21121-01-N-12-03), and Taipei Medical University (TMU109-AE1-B15) awarded to Kuei-Hung Lai. The authors are thankful the High Valued Instrument Center, National Sun Yat-sen University, for the mass (MS000600) and NMR (NMR001100) Spectra (MOST 110-2731-M-110-001); and to the Instrumentation Center, National Taiwan University for providing X-ray facilities (MOST 110?2731-M-002?001, XRD000200). Publisher Copyright: © 2021 The Author(s)

PY - 2022/4/5

Y1 - 2022/4/5

N2 - A chemical investigation was carried out on a feather star Comanthus parvicirrus collected from the waters of Southern Taiwan, which led to the isolation of three angular naphthopyrones (1–3), including one new metabolite, 8‑hydroxy-5,6,9,10-tetramethoxy-2-methyl-4H-benzo[h]chromen-4-one (1). The structures of compounds 1–3 were assigned based on spectroscopic methods, including UV, MS, 1D- and 2D-NMR spectra, and the structure of 1 was established by single-crystal X-ray diffraction analysis directly. The compound 3 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

AB - A chemical investigation was carried out on a feather star Comanthus parvicirrus collected from the waters of Southern Taiwan, which led to the isolation of three angular naphthopyrones (1–3), including one new metabolite, 8‑hydroxy-5,6,9,10-tetramethoxy-2-methyl-4H-benzo[h]chromen-4-one (1). The structures of compounds 1–3 were assigned based on spectroscopic methods, including UV, MS, 1D- and 2D-NMR spectra, and the structure of 1 was established by single-crystal X-ray diffraction analysis directly. The compound 3 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

KW - Comanthus parvicirrus

KW - Crinoid

KW - Feather star

KW - iNOS

KW - Naphthopyrone

KW - X-ray

UR - https://www.scopus.com/pages/publications/85121935157

UR - https://www.scopus.com/pages/publications/85121935157#tab=citedBy

U2 - 10.1016/j.molstruc.2021.132261

DO - 10.1016/j.molstruc.2021.132261

M3 - Article

AN - SCOPUS:85121935157

SN - 0022-2860

VL - 1253

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 132261

ER -

A new angular naphthopyrone from feather star Comanthus parvicirrus (Müller, 1841)

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 2117795: Experimental Crystal Structure Determination

引用此