A model for tumor cell killing by topoisomerase poisons

H. Zhang; P. D'Arpa; Leroy-Fong Liu

A model for tumor cell killing by topoisomerase poisons

H. Zhang, P. D'Arpa, Leroy-Fong Liu

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

原文	英語
頁（從 - 到）	23-26
頁數	4
期刊	Cancer Cells
卷	2
發行號	1
出版狀態	已發佈 - 1990
對外發佈	是

ASJC Scopus subject areas

癌症研究

UN SDG

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引用此

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title = "A model for tumor cell killing by topoisomerase poisons",

abstract = "Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.",

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AU - Zhang, H.

AU - D'Arpa, P.

AU - Liu, Leroy-Fong

PY - 1990

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N2 - Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

AB - Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

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M3 - Article

C2 - 2167111

AN - SCOPUS:0025276858

SN - 1042-2196

VL - 2

SP - 23

EP - 26

JO - Cancer Cells

JF - Cancer Cells

IS - 1

ER -

A model for tumor cell killing by topoisomerase poisons

摘要

ASJC Scopus subject areas

UN SDG

其它文件與鏈接

指紋

引用此