摘要
Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.
原文 | 英語 |
---|---|
頁(從 - 到) | 1843-1848 |
頁數 | 6 |
期刊 | Journal of Virology |
卷 | 88 |
發行號 | 3 |
DOIs | |
出版狀態 | 已發佈 - 2月 1 2014 |
ASJC Scopus subject areas
- 微生物學
- 免疫學
- 昆蟲科學
- 病毒學