A fully integrated nose-on-a-chip for rapid diagnosis of ventilator-associated pneumonia

Shih Wen Chiu, Jen Huo Wang, Kwuang Han Chang, Ting Hau Chang, Chia Min Wang, Chia Lin Chang, Chen Ting Tang, Chien Fu Chen, Chung-Hung Shih, Han Wen Kuo, Li Chun Wang, Hsin Chen, Chih Cheng Hsieh, Meng Fan Chang, Yi Wen Liu, Tsan Jieh Chen, Chia Hsiang Yang, Herming Chiueh, Juyo Min Shyu, Kea Tiong Tang

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)


Ventilator-associated pneumonia (VAP) still lacks a rapid diagnostic strategy. This study proposes installing a nose-on-a-chip at the proximal end of an expiratory circuit of a ventilator to monitor and to detect metabolite of pneumonia in the early stage. The nose-on-a-chip was designed and fabricated in a 90-nm 1P9M CMOS technology in order to downsize the gas detection system. The chip has eight on-chip sensors, an adaptive interface, a successive approximation analog-to-digital converter (SAR ADC), a learning kernel of continuous restricted Boltzmann machine (CRBM), and a RISC-core with low-voltage SRAM. The functionality of VAP identification was verified using clinical data. In total, 76 samples infected with pneumonia (19 Klebsiella, 25 Pseudomonas aeruginosa, 16 Staphylococcus aureus, and 16 Candida) and 41 uninfected samples were collected as the experimental group and the control group, respectively. The results revealed a very high VAP identification rate at 94.06% for identifying healthy and infected patients. A 100% accuracy to identify the microorganisms of Klebsiella, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida from VAP infected patients was achieved. This chip only consumes 1.27 mW at a 0.5 V supply voltage. This work provides a promising solution for the long-term unresolved rapid VAP diagnostic problem.
頁(從 - 到)765-778
期刊IEEE Transactions on Biomedical Circuits and Systems
出版狀態已發佈 - 12月 1 2014

ASJC Scopus subject areas

  • 電氣與電子工程
  • 生物醫學工程
  • 一般醫學


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