A double-blind randomized controlled trial of colchicine in patients with hepatitis B virus-related postnecrotic cirrhosis

Yuan Jen Wang, Shou Dong Lee, Mao Chih Hsieh, Han Chieh Lin, Fa Yauh Lee, Shyh Haw Tsay, Yang Te Tsai, Oliver Yoa Pu Hu, Ming Lu King, Kwang Juei Lo

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The preliminary results of a prospective double-blind controlled trial of colchicine in 100 patients with hepatitis B virus-related cirrhosis are reported. The patients, 94 males and 6 females, aged 32-80, were assigned to receive either 1 mg of colchicine or an identical placebo orally on a daily basis. The duration of the follow up ranged from 15 to 51 months (median 26 months). Seventy percent had histological proof of cirrhosis. On entry, 80 patients were in Child-Pugh class A, 19 were in class B, and one was in class C. Compared to the placebo group, there was no improvement in the colchicine group after a 24-month follow up in any of the biochemistry data, for example, serum albumin, alkaline phosphatase, alanine and aspartate aminotransferase, bilirubin, and prothrombin time. The difference in the cumulative survival rates at 51 months did not reach statistical significance (p=0.8) in either group. There was no histological improvement in 30 patients who were willing to undergo repeated liver biopsies. No trend toward improvement of the hepatic pressure gradient was observed in these patients. The serum levels of aminopropeptide of type III procollagen increased significantly in patients in both groups after 24 months of therapy (1.07±0.06 vs. 1.36±0.06 U/ml in the colchicine group, 0.93±0.09 vs. 1.25±0.07 U/ml in the placebo group; p<0.05). In addition, neither the clinical deterioration of cirrhosis nor death was prevented in patients receiving colchicine therapy. This report indicates that colchicine has no effect in the treatment of HBV-related postnecrotic cirrhosis.
原文英語
頁(從 - 到)872-877
頁數6
期刊Journal of Hepatology
21
發行號5
DOIs
出版狀態已發佈 - 1月 1 1994
對外發佈

ASJC Scopus subject areas

  • 肝病

指紋

深入研究「A double-blind randomized controlled trial of colchicine in patients with hepatitis B virus-related postnecrotic cirrhosis」主題。共同形成了獨特的指紋。

引用此