A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration

Yow Shieng Uang, Kuang Yang Hsu

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)


The dose-dependent pharmacokinetics of caffeic acid (CA) were studied in rabbits. Three different doses (5, 10, and 25mg kg-1) were administered intravenously to six rabbits each. The concentration-time profiles for CA could be fitted by a two-compartment model for each dose. The results showed that total-body clearance and elimination rate constant from the central compartment (k10) after a 5 mg kg-1 dose were greater than those after the other two doses. Furthermore, the terminal elimination half-life (β half-life) and mean residence time (MRT) after a 5 mg kg-1 dose were less than after the other doses. The AUC value increased linearly with dose within the range of 10-25 mg kg-1. Most of the unchanged caffeic acid was excreted in the urine within 2 h. The percentage of unchanged caffeic acid excreted in the urine was 63.4, 60.0, and 55.4% after doses of 5, 10, and 25 mg kg-1, respectively, which was not significantly different. However, significant differences in the renal clearances and renal excretion rate constants were observed with a 5 mg kg-1 dose compared to the other doses. On the other hand, nonrenal clearances and nonrenal excretion rate constants showed no dose-related differences. The differences observed in total-body clearance, k10, β half-life, and MRT between a 5 mg kg-1 dose and the ether doses can be explained on the basis of the differences in renal clearance and renal excretion rate constants.

頁(從 - 到)727-736
期刊Biopharmaceutics and Drug Disposition
出版狀態已發佈 - 1997

ASJC Scopus subject areas

  • 藥學(醫學)
  • 藥理
  • 藥學科學


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