A Deep Learning and PSSM Profile Approach for Accurate SNARE Protein Prediction

Quang Hien Kha, Huu Phuc Lam Nguyen, Nguyen Quoc Khanh Le

研究成果: 雜誌貢獻文章同行評審

摘要

SNARE proteins play a pivotal role in membrane fusion and various cellular processes. Accurate identification of SNARE proteins is crucial for elucidating their functions in both health and disease contexts. This chapter presents a novel approach employing multiscan convolutional neural networks (CNNs) combined with position-specific scoring matrix (PSSM) profiles to accurately recognize SNARE proteins. By leveraging deep learning techniques, our method significantly enhances the accuracy and efficacy of SNARE protein classification. We detail the step-by-step methodology, including dataset preparation, feature extraction using PSI-BLAST, and the design of the multiscan CNN architecture. Our results demonstrate that this approach outperforms existing methods, providing a robust and reliable tool for bioinformatics research.
原文英語
頁(從 - 到)79-89
頁數11
期刊Methods in molecular biology (Clifton, N.J.)
2887
DOIs
出版狀態已發佈 - 2025

ASJC Scopus subject areas

  • 分子生物學
  • 遺傳學

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