TY - JOUR
T1 - A Deep Learning and PSSM Profile Approach for Accurate SNARE Protein Prediction
AU - Kha, Quang Hien
AU - Nguyen, Huu Phuc Lam
AU - Le, Nguyen Quoc Khanh
N1 - Publisher Copyright:
© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2025
Y1 - 2025
N2 - SNARE proteins play a pivotal role in membrane fusion and various cellular processes. Accurate identification of SNARE proteins is crucial for elucidating their functions in both health and disease contexts. This chapter presents a novel approach employing multiscan convolutional neural networks (CNNs) combined with position-specific scoring matrix (PSSM) profiles to accurately recognize SNARE proteins. By leveraging deep learning techniques, our method significantly enhances the accuracy and efficacy of SNARE protein classification. We detail the step-by-step methodology, including dataset preparation, feature extraction using PSI-BLAST, and the design of the multiscan CNN architecture. Our results demonstrate that this approach outperforms existing methods, providing a robust and reliable tool for bioinformatics research.
AB - SNARE proteins play a pivotal role in membrane fusion and various cellular processes. Accurate identification of SNARE proteins is crucial for elucidating their functions in both health and disease contexts. This chapter presents a novel approach employing multiscan convolutional neural networks (CNNs) combined with position-specific scoring matrix (PSSM) profiles to accurately recognize SNARE proteins. By leveraging deep learning techniques, our method significantly enhances the accuracy and efficacy of SNARE protein classification. We detail the step-by-step methodology, including dataset preparation, feature extraction using PSI-BLAST, and the design of the multiscan CNN architecture. Our results demonstrate that this approach outperforms existing methods, providing a robust and reliable tool for bioinformatics research.
KW - Bioinformatics
KW - Convolutional neural networks (CNN)
KW - Deep learning
KW - Position-specific scoring matrix (PSSM)
KW - Protein classification
KW - SNARE proteins
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U2 - 10.1007/978-1-0716-4314-3_5
DO - 10.1007/978-1-0716-4314-3_5
M3 - Article
C2 - 39806147
AN - SCOPUS:85215558950
SN - 1064-3745
VL - 2887
SP - 79
EP - 89
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -