A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect

Bo Tsang Huang, Wei Yun Lai, Yi Chung Chang, Jen Wei Wang, Shauh Der Yeh, Emily Pei Ying Lin, Pan Chyr Yang

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)


The successful translation of cytotoxic T lymphocyte antigen-4 (CTLA-4) blockade has revolutionized the concept of cancer immunotherapy. Although monoclonal antibody therapeutics remain the mainstream in clinical practice, aptamers are synthetic oligonucleotides that encompass antibody-mimicking functions. Here, we report a novel high-affinity CTLA-4-antagonizing DNA aptamer (dissociation constant, 11.84 nM), aptCTLA-4, which was identified by cell-based SELEX and high-throughput sequencing. aptCTLA-4 is relatively stable in serum, promotes lymphocyte proliferation, and inhibits tumor growth in cell and animal models. Our study demonstrates the developmental pipeline of a functional CTLA-4-targeting aptamer and suggests a translational potential for aptCTLA-4.

頁(從 - 到)520-528
期刊Molecular Therapy - Nucleic Acids
出版狀態已發佈 - 9月 15 2017

ASJC Scopus subject areas

  • 分子醫學
  • 藥物發現


深入研究「A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect」主題。共同形成了獨特的指紋。