A Cross-Platform Comparison of Affymetrix, Agilent, and Illumina Microarray Reveals Functional Genomics in Colorectal Cancer Progression

Hendrick Gao Min Lim, Yuan Chii Gladys Lee

研究成果: 書貢獻/報告類型會議貢獻

2 引文 斯高帕斯(Scopus)

摘要

Colorectal cancer is one of the most common cancers with the second highest mortality rate in the world. The microarray can be used to collect gene expression alteration information from many tissue samples that will be useful to understand colorectal cancer from the molecular level. However, the mechanism behind the progression from normal to cancer is not fully understood. Here, a cross-platform comparison among three common microarray platforms (Affymetrix, Agilent, and Illumina) was applied. As results, we found a significant correlation of purine metabolism and p53 signaling pathway role in colorectal cancer progression. Purine metabolism can control the regulation of cell proliferation which involve hydro-lyase activity on organelle lumen. Meanwhile, genetic alterations in p53 signaling pathways could control some hallmarks of cancer. These two terms might play important roles in inducing normal colorectal cells into cancer.
原文英語
主出版物標題2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
發行者Institute of Electrical and Electronics Engineers Inc.
頁面252-255
頁數4
ISBN(電子)9781538613115
DOIs
出版狀態已發佈 - 7月 2019
事件41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, 德国
持續時間: 7月 23 20197月 27 2019

出版系列

名字Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN(列印)1557-170X

會議

會議41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
國家/地區德国
城市Berlin
期間7/23/197/27/19

ASJC Scopus subject areas

  • 訊號處理
  • 生物醫學工程
  • 電腦視覺和模式識別
  • 健康資訊學

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