A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

Hui‐Po ‐P Wang; On Lee; Chin‐Tsai ‐T Fan; Lain‐Tze ‐T Lee

doi:10.1002/jccs.199500075

A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

Hui‐Po ‐P Wang, On Lee, Chin‐Tsai ‐T Fan, Lain‐Tze ‐T Lee

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

摘要

A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.

原文	英語
頁（從 - 到）	569-572
頁數	4
期刊	Journal of the Chinese Chemical Society
卷	42
發行號	3
DOIs	https://doi.org/10.1002/jccs.199500075
出版狀態	已發佈 - 6月 1995
對外發佈	是

ASJC Scopus subject areas

一般化學

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10.1002/jccs.199500075

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title = "A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil",

abstract = "A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.",

keywords = "2,2‐DimethyI‐5‐(2,5‐dimethylphenoxy)‐3‐hydroxypentanoic acid β‐lactone, 2,2‐Dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid, Dimetnylketene, Gemfibrozil, [2+2] cycloaddition",

author = "Wang, {Hui‐Po ‐P} and On Lee and Fan, {Chin‐Tsai ‐T} and Lee, {Lain‐Tze ‐T}",

year = "1995",

month = jun,

doi = "10.1002/jccs.199500075",

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AU - Wang, Hui‐Po ‐P

AU - Lee, On

AU - Fan, Chin‐Tsai ‐T

AU - Lee, Lain‐Tze ‐T

PY - 1995/6

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N2 - A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.

AB - A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.

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KW - 2,2‐Dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid

KW - Dimetnylketene

KW - Gemfibrozil

KW - [2+2] cycloaddition

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A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

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