A community-based RCT for oral cancer screening with toluidine blue

W. W.Y. Su, A. M.F. Yen, S. Y.H. Chiu, T. H.H. Chen

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30 引文 斯高帕斯(Scopus)


Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10-5) was non-significantly 21% lower than that in the control group (35.4 × 10-5).
頁(從 - 到)933-937
期刊Journal of Dental Research
出版狀態已發佈 - 9月 2010

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