A case of multiple sclerosis with initial symptoms of narcolepsy

C. Y. Wang, H. Kawashima, T. Takami, N. Yamada, T. Miyajima, M. Ogihara, K. Takekuma, A. Hoshika

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)


We reported a 13-year-old boy diagnosed as multiple sclerosis associated with narcolepsy. He had suffered from retrobulbar optic neuritis at the age of 11 years which was improved gradually by prednisolone. Four months later he was admitted because of excessive somnolence. The diagnosis of narcolepsy was made based on hypnagogic hallucination, sleep paralysis, changes of personality and the sleep onset sREM (SOREM). The elevation of anti-measles antibody and a positive oligoclonal band in CSF, low density areas in the bilateral internal capsule on CT scan, and high signal areas in the same region on T2-weighted MRI confirmed the diagnosis of multiple sclerosis. An abnormal arousal response occurred occassionally in sleep stage 2 and 4, which started with electrical silence followed by a period with irregular high voltage slow waves and repetitive focal spike train. Those clinical symptoms and abnormalities of biochemical and electrophysiological studies normalized after treatment with prednisolone. However, abnormalities on MRI showed no improvement even after long term administration of prednisolone (2.5 mg/day).

頁(從 - 到)300-306
期刊No To Hattatsu
出版狀態已發佈 - 1998

ASJC Scopus subject areas

  • 神經病學(臨床)
  • 兒科、圍產兒和兒童健康


深入研究「A case of multiple sclerosis with initial symptoms of narcolepsy」主題。共同形成了獨特的指紋。