Aβ Aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides

Shwu Jiuan Lin; Young Ji Shiao; Chih Wen Chi; Li Ming Yang

doi:10.1016/j.bmcl.2003.12.086

Aβ Aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides

Shwu Jiuan Lin, Young Ji Shiao, Chih Wen Chi, Li Ming Yang

研究成果: 雜誌貢獻 › 文章 › 同行評審

24 引文斯高帕斯（Scopus）

摘要

Phenylazo benzenesulfonamides were designed and synthesized as β-amyloid (Aβ40) fibril assembly inhibitors, and evaluated for inhibition of Aβ40 aggregation and neurotoxicity using rat cortical neurons. Compound 2 (LB-152) was the most potent compound in this study, and the para-NMe2 group on the end of the phenylazo moiety may play an important role in preventing Aβ40 fibril formation. LB-152 provides a new lead for further development of potential β-amyloid aggregation inhibitors to treat AD.

原文	英語
頁（從 - 到）	1173-1176
頁數	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	14
發行號	5
DOIs	https://doi.org/10.1016/j.bmcl.2003.12.086
出版狀態	已發佈 - 3月 8 2004

Keywords

Alzheimer's disease
Benzenesulfonamide
beta-Amyloid
Phenylazo

ASJC Scopus subject areas

生物化學
分子生物學
有機化學
藥物發現
藥學科學

存取文件

10.1016/j.bmcl.2003.12.086

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Link to publication in Scopus

引用此

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abstract = "Phenylazo benzenesulfonamides were designed and synthesized as β-amyloid (Aβ40) fibril assembly inhibitors, and evaluated for inhibition of Aβ40 aggregation and neurotoxicity using rat cortical neurons. Compound 2 (LB-152) was the most potent compound in this study, and the para-NMe2 group on the end of the phenylazo moiety may play an important role in preventing Aβ40 fibril formation. LB-152 provides a new lead for further development of potential β-amyloid aggregation inhibitors to treat AD.",

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author = "Lin, {Shwu Jiuan} and Shiao, {Young Ji} and Chi, {Chih Wen} and Yang, {Li Ming}",

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AU - Yang, Li Ming

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KW - Phenylazo

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KW - beta-Amyloid

KW - Phenylazo

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Aβ Aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides

摘要

Keywords

ASJC Scopus subject areas

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