5β,19-Epoxycucurbitane triterpenoids from momordica charantia and their anti-inflammatory and cytotoxic activity

Chia Ching Liaw; Hui Chi Huang; Ping Chun Hsiao; Li Jie Zhang; Zhi Hu Lin; Syh Yuan Hwang; Feng Lin Hsu; Yao Haur Kuo

doi:10.1055/s-0034-1383307

5β,19-Epoxycucurbitane triterpenoids from momordica charantia and their anti-inflammatory and cytotoxic activity

Chia Ching Liaw, Hui Chi Huang, Ping Chun Hsiao, Li Jie Zhang, Zhi Hu Lin, Syh Yuan Hwang, Feng Lin Hsu, Yao Haur Kuo

研究成果: 雜誌貢獻 › 文章 › 同行評審

34 引文斯高帕斯（Scopus）

摘要

ive new 5β,19-epoxycucurbitane triterpenoids, taikugausins A-E (1 -5), together with 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (6), have been isolated and characterized from the 70% EtOH extract of the fresh fruits of Momordica charantia. The chemical structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analyses, especially 2D NMR (HMQC, HMBC, and NOESY) experiments and HRESIMS data. The relationship between NMR chemical shifts and the configuration of C-19 with an OMe group in 5β,19-epoxycucurbitane are described. Among them, compounds 3 and 4 exhibited remarkable anti-inflammatory activities by the inhibition of nitric oxide production at the concentration of 10 μg/mL. In addition, 3 and 4 also showed moderate cytotoxicity against WiDr, Hep G2, MCF-7, and HEp-2 human tumor cell lines. © Georg Thieme Verlag KG.

原文	英語
頁（從 - 到）	62-70
頁數	9
期刊	Planta Medica
卷	81
發行號	1
DOIs	https://doi.org/10.1055/s-0034-1383307
出版狀態	已發佈 - 12月 3 2015

ASJC Scopus subject areas

分析化學
分子醫學
藥理
藥學科學
藥物發現
補充和替代醫學
有機化學

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10.1055/s-0034-1383307

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title = "5β,19-Epoxycucurbitane triterpenoids from momordica charantia and their anti-inflammatory and cytotoxic activity",

abstract = "Five new 5β,19-epoxycucurbitane triterpenoids, taikugausins A-E (1 -5), together with 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (6), have been isolated and characterized from the 70% EtOH extract of the fresh fruits of Momordica charantia. The chemical structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analyses, especially 2D NMR (HMQC, HMBC, and NOESY) experiments and HRESIMS data. The relationship between NMR chemical shifts and the configuration of C-19 with an OMe group in 5β,19-epoxycucurbitane are described. Among them, compounds 3 and 4 exhibited remarkable anti-inflammatory activities by the inhibition of nitric oxide production at the concentration of 10 μg/mL. In addition, 3 and 4 also showed moderate cytotoxicity against WiDr, Hep G2, MCF-7, and HEp-2 human tumor cell lines.",

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AU - Hsiao, Ping Chun

AU - Zhang, Li Jie

AU - Lin, Zhi Hu

AU - Hwang, Syh Yuan

AU - Hsu, Feng Lin

AU - Kuo, Yao Haur

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5β,19-Epoxycucurbitane triterpenoids from momordica charantia and their anti-inflammatory and cytotoxic activity

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