4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

Jerome G. Ganzon, Lih Geeng Chen, Ching Chiung Wang

研究成果: 雜誌貢獻文章同行評審

33 引文 斯高帕斯(Scopus)


Mulberry (Morus alba L.) leaves are widely used as herbal tea to prevent heat stroke. Potential chemical markers of the antioxidant properties and its correlation with harvesting times and leaf location were explored in this study. A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay guided isolation of mulberry leaves extract provided five phenolic compounds: 5-O-caffeoylquinic acid (1), 4-O-caffeoylquinic acid (2), gastrodin (3), isoquercetin (4) and rutin (5). The 50% radical-scavenging concentrations (SC50) of these compounds were 32.76 ± 0.27, 11.41 ± 0.48, 404.30 ± 4.92, 10.63 ± 0.96, and 10.57 ± 0.61 μg/mL, respectively. Chromatographic fingerprinting allowed content analysis of 1–5 in samples over a 12-month period. Compounds 1–5 were abundance in apical leaves (0–10 cm) in January and February at temperatures < 20 °C. Contents of 2 and 5 were highest in these months and were strongly correlated to the antioxidant property. Therefore, we suggested that the mulberry leaves harvested during January and February have high yield of 4-O-caffeoylquinic acid and this compound can be used as antioxidative marker in mulberry leaves.
期刊Journal of Food and Drug Analysis
出版狀態已發佈 - 2018


  • 4-O-Caffeoylquinic acid
  • Antioxidant
  • Harvest time
  • Morus alba

ASJC Scopus subject areas

  • 食品科學
  • 藥理


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