3D scaffold with PCL combined biomedical ceramic materials for bone tissue regeneration

Ming Jyh Chern, Liang Yo Yang, Yung Kang Shen, Jia Hsiang Hung

研究成果: 雜誌貢獻文章同行評審

25 引文 斯高帕斯(Scopus)


Three-dimensional porous biodegradable polymer scaffolds have been widely used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study selects the Poly-e{open}-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA) or nano-aluminum oxide (nAl2O3) for porous scaffold. This study uses the solvent casting/particulate leaching method to fabricate the porous scaffold. The authors discuss the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA, PCL/nHA and PCL/nAl2O3 scaffolds. In vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA and nAl2O3 can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis.
頁(從 - 到)2201-2207
期刊International Journal of Precision Engineering and Manufacturing
出版狀態已發佈 - 12月 2013

ASJC Scopus subject areas

  • 機械工業
  • 工業與製造工程
  • 電氣與電子工程


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