2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Yu Tang Chin, Meng Ti Hsieh, Chi Yu Lin, Po Jan Kuo, Yu Chen S H Yang, Ya Jung Shih, Hsuan Yu Lai, Guei Yun Cheng, Heng Yuan Tang, Chen Chen Lee, Sheng Yang Lee, Ching Chiung Wang, Hung Yun Lin, Earl Fu, Jacqueline Whang-Peng, Leroy F. Liu

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31 引文 斯高帕斯(Scopus)


Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4′-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. Human gingival fibroblast cells were treated with lipopolysaccharide (LPS) extracted from P. gingivalis in the presence of resveratrol or THSG to analyze the expression of TNF-α, IL-1β, and IL-6 genes. Increased AMP-activated protein kinase (AMPK) activation and SirT1 expression were induced by THSG. Treatment of THSG decreased the expression of LPS-induced inflammatory cytokines, enhanced AMPK activation, and increased the expression of SirT1. In addition, it suppressed the activation of NF-B when cells were stimulated with P. gingivalis LPS. The anti-inflammatory effect of THSG and P. Multiflori crude extracts was reproduced in ligature-induced periodontitis animal modeling. In conclusion, THSG inhibited the inflammatory responses of P. gingivalis-stimulated human gingival fibroblasts and ameliorated ligature-induced periodontitis in animal model.
期刊Mediators of Inflammation
出版狀態已發佈 - 2016

ASJC Scopus subject areas

  • 免疫學
  • 細胞生物學


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