TY - JOUR
T1 - 18F-FDG PET or PET/CT for detecting extensive disease in small-cell lung cancer
T2 - A systematic review and meta-analysis
AU - Lu, Yu Yu
AU - Chen, Jin Hua
AU - Liang, Ji An
AU - Chu, Shannon
AU - Lin, Wan Yu
AU - Kao, Chia Hung
PY - 2014/7
Y1 - 2014/7
N2 - The purpose of this study was to conduct a systematic review and meta-analysis of the published literature to evaluate the diagnostic accuracy of fluorine-18 2-fluoro-2-deoxy-D-glucose (F-FDG) PET or PET/computed tomography (CT) in the pretherapeutic staging of patients with small-cell lung cancer (SCLC). The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated the pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and summary receiver operating characteristic curves in the detection of extensive disease (ED) in patients with SCLC. Twelve studies with a total of 369 patients met the inclusion criteria. The pooled estimates of sensitivity, specificity, LR+, and LR-of F-FDG PET or PET/CT for the detection of ED in SCLC were 97.5% [95% confidence interval (CI), 94.2-99.2%], 98.2% (95% CI, 94.9-99.6%), 19.86 (95% CI, 9.79-40.30), and 0.06 (95% CI, 0.03-0.10), respectively. Whole-body F-FDG PET or PET/CT is a valuable imaging tool for the pretherapeutic assessment of ED in patients with SCLC.
AB - The purpose of this study was to conduct a systematic review and meta-analysis of the published literature to evaluate the diagnostic accuracy of fluorine-18 2-fluoro-2-deoxy-D-glucose (F-FDG) PET or PET/computed tomography (CT) in the pretherapeutic staging of patients with small-cell lung cancer (SCLC). The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated the pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and summary receiver operating characteristic curves in the detection of extensive disease (ED) in patients with SCLC. Twelve studies with a total of 369 patients met the inclusion criteria. The pooled estimates of sensitivity, specificity, LR+, and LR-of F-FDG PET or PET/CT for the detection of ED in SCLC were 97.5% [95% confidence interval (CI), 94.2-99.2%], 98.2% (95% CI, 94.9-99.6%), 19.86 (95% CI, 9.79-40.30), and 0.06 (95% CI, 0.03-0.10), respectively. Whole-body F-FDG PET or PET/CT is a valuable imaging tool for the pretherapeutic assessment of ED in patients with SCLC.
KW - PET/CT
KW - small-cell lung cancer
KW - staging
UR - http://www.scopus.com/inward/record.url?scp=84902267172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902267172&partnerID=8YFLogxK
U2 - 10.1097/MNM.0000000000000122
DO - 10.1097/MNM.0000000000000122
M3 - Review article
C2 - 24694775
AN - SCOPUS:84902267172
SN - 0143-3636
VL - 35
SP - 697
EP - 703
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
IS - 7
ER -
