以acridine為scaffold透過雙標靶策略發展新穎抗癌藥物(2/3)

Pharmacology, Toxicology and Pharmaceutical Science

1. Acridine 100%
2. Anticancer Drug 100%
3. Antitumor Activity 16%
4. Camptothecin 16%
5. Clinical Trial 16%
6. Cytotoxicity 33%
7. DNA Topoisomerase 100%
8. DNA Topoisomerase Inhibitor 66%
9. Hematologic Malignancy 16%
10. Histone Deacetylase 66%
11. Histone Deacetylase Inhibitor 83%
12. Hydroxamic Acid 33%
13. Lead Compound 16%
14. Malignant Neoplasm 33%
15. N (2 Dimethylaminoethyl) 4 Acridinecarboxamide 50%
16. Pharmacokinetics 16%
17. Side Effect 16%
18. Solid Malignant Neoplasm 66%
19. Structure Activity Relationship 50%
20. Triazole 16%
21. Vorinostat 50%