Development of Novel Two Photon Responsive Non-Classical Chromo-Fluorogenic Functional Materials for Alzheimer’S Disease Diagnostics and Therapeutics: a Step towards Future Translational Medicine

Site-specific chromo-fluorogenic AD biomarkers recognition and therapeutic is a cutting-edge research theme, as until today the exact cause for anomalous folding of Amyloid Beta and tau proteins in cellular conditions are not known. To investigate pathogenic proteins, and their folding mechanism in cells and invivo models we are aiming to develop simple and cost-effective non-invasive label-free and labelled diagnostic and therapeutic materials. Lack of efficient point-of-care chromo-fluorogenic diagnostic tools to identify the early-stage AD biomarkers with good therapeutic efficacy under TP excitations (ex> 850 nm), inspired us to write a proposal on this topic. Novel fluorescent biomarkers that can selectively recognize the Amyloid Beta and NFTs pathogenesis with good therapeutic efficacy would provide novel insights into biochemical aspects of AD disease progression in neural cells/tissues. To achieve diagnostic and therapeutic goals (“translational medicine”) under one roof a new TP-responsive material has been proposed in the current research grant. Even though this proposal has novel insights towards the development of efficient AD biomarkers diagnostics and therapeutics in a sustainable and economical way, there are a few hurdles that would create obstacles to achieving this goal, such as excretion of nano-materials from invivo models, side effects towards normal neural tissues after therapy and cytotoxic effects towards surrounding tissues. In this project we are aiming for long-term goals, towards clinical applications and commercialization, time to time necessary strategic plans will be implemented to achieve sustainable translational medicine for AD. Therefore, we would expect this research will end up with patents (PI inventor of one patent), several publications, a graduation thesis along with technology transfer.