多重模式取向探討躁期與鬱期下精神運動之神經生物的變化(2/2)

研究計畫: A - 政府部門b - 國家科學及技術委員會

專案詳細資料

說明

The proposed study aims to investigate the neural basis of psychomotor alterations across the various phases (mania, depression, and euthymia) of bipolar disorder (BD), by using a dimensional Research Domain Criteria (RDoC)-like and multimodal approach. In particular, we will characterize, for the first time, the specific relationships between psychomotor changes (as measured by objective methods with actigraphy) and intrinsic brain activity, from neuronal oscillations in the high-frequency range (as measured by electroencephalography) to large-scale network balancing and its subcortical modulation in the low-frequency range (as measured by resting-state functional magnetic imaging). The results from this study will allow us to parse the clinical heterogeneity of BD by focusing on one of its core clinical feature, such as psychomotor changes, and comprehensively map such behavioral alterations onto specific neural circuits across the full range of intrinsic neuronal oscillations. Moreover, this model may be generalized and applied trans-diagnostically to other major psychiatric disorders, including schizophrenia and major depression, by using a dimensional approach. These results could even provide further information on the functional architecture of intrinsic brain activity underlying the psychomotor behavior in general. Our findings will be described in written papers and published in international Journals of neuroscience and psychiatry, as well as disseminated at conferences. Our study could also provide us with rich information to serve as a basis to translate into diagnostic and therapeutic applications. The individuation of different subgroups of patients characterized by specific and homogenous alterations at both behavioral and neural levels will assist in the diagnostic assessment and help to implement new, individualized, and more effective therapies that have a neuroscientific basis, such as non-invasive brain stimulation therapies specifically targeting the abnormal oscillation patterns in intrinsic brain activity.
狀態已完成
有效的開始/結束日期8/1/217/31/23

Keywords

  • 躁期
  • 鬱期
  • 精神運動改變
  • 內生性大腦活動
  • 靜息狀態網絡
  • 神經震盪頻率範圍
  • 腕動計
  • 靜息狀態功能性磁振造影
  • 腦波圖

指紋

探索此專案觸及的研究主題。這些標籤是根據基礎獎勵/補助款而產生。共同形成了獨特的指紋。