Wen-Chi Hou

2025

2-Hydroxyl hispolon reverses high glucose-induced endothelial progenitor cell dysfunction through the PI3K/Akt/eNOS and AMPK/HO-1 pathways

Wang, T. J., Hou, W. C., Hsiao, B. Y., Lo, T. H., Chen, Y. T., Yang, C. H., Shih, Y. T. & Liu, J. C., 2025, (接受/付印) 於: British Journal of Pharmacology.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

2024

Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice

Yang, C. H., Li, C. W., Sie, Y. Y., Chen, L. C., Yuan, Y. H. & Hou, W. C., 12月 2024, 於: Botanical Studies. 65, 1, 38.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Consumption of carotenoid-rich Momordica cochinchinensis (Gac) aril improves glycemic control in type 2 diabetic mice partially through taste receptor type 1 mediated glucagon-like peptide 1 secretion

Hsieh, Y. Y., Hou, W. C., Hsu, S. J., Liaw, C. C., Huang, C., Shih, M. C. M., Shen, Y. C., Chen, Y. F., Lee, C. K., Lee, O. K., Wu, C. C., Lee, I. J., Cheng, J. J., Hou, Y. C. & Liu, H. K., 11月 13 2024, 於: Food and Function. 15, 23, p. 11415-11431 17 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

2023

Extracts and Scirpusin B from Recycled Seeds and Rinds of Passion Fruits (Passiflora edulis var. Tainung No. 1) Exhibit Improved Functions in Scopolamine-Induced Impaired-Memory ICR Mice

Sie, Y. Y., Chen, L. C., Li, C. W., Wang, C. C., Li, C. J., Liu, D. Z., Lee, M. H., Chen, L. G. & Hou, W. C., 12月 2023, 於: Antioxidants. 12, 12, 2058.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

3 引文斯高帕斯（Scopus）

Inhibition of Acetylcholinesterase and Amyloid-β Aggregation by Piceatannol and Analogs: Assessing In Vitro and In Vivo Impact on a Murine Model of Scopolamine-Induced Memory Impairment

Sie, Y.-Y., Chen, L.-C., Li, C.-J., Yuan, Y.-H., Hsiao, S.-H., Lee, M.-H., Wang, C.-C. & Hou, W.-C., 2023, 於: Antioxidants. 12, 7

研究成果: 雜誌貢獻 › 文章 › 同行評審

13 引文斯高帕斯（Scopus）

Vitisin B, a resveratrol tetramer from Vitis thunbergii var. taiwaniana, ameliorates impaired glucose regulations in nicotinamide/streptozotocin-induced type 2 diabetic mice

Liu, Y. H., Lin, Y. S., Sie, Y. Y., Wang, C. C., Chang, C. I. & Hou, W. C., 2023, (接受/付印) 於: Journal of Traditional and Complementary Medicine. 13, 5, p. 479-488 10 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

1 引文斯高帕斯（Scopus）

2022

Anti-adipogenic activities of pheophorbide a and pyropheophorbide a isolated from wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) in vitro

Liu, Y. H., Lu, Y. L., Chang, Y. C., Chyuan, J. H., Lee, T. H. & Hou, W. C., 2022, (接受/付印) 於: Journal of the Science of Food and Agriculture. 102, 14, p. 6771-6779 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

4 引文斯高帕斯（Scopus）

Vitisin A, a Resveratrol Tetramer, Improves Scopolamine-Induced Impaired Learning and Memory Functions in Amnesiac ICR Mice

Chen, L. G., Wang, C. C., Lee, Y. S., Sie, Y. Y., Chang, C. I. & Hou, W. C., 2月 2022, 於: Biomedicines. 10, 2, 273.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

11 引文斯高帕斯（Scopus）

2021

Dietary supplementation of rutin and rutin-rich buckwheat elevates endogenous glucagon-like peptide 1 levels to facilitate glycemic control in type 2 diabetic mice

Lee, L. C., Hou, Y. C., Hsieh, Y. Y., Chen, Y. H., Shen, Y. C., Lee, I. J., Monica Shih, M. C., Hou, W. C. & Liu, H. K., 10月 2021, 於: Journal of Functional Foods. 85, 104653.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

30 引文斯高帕斯（Scopus）

Hydrolysable tannins exhibit acetylcholinesterase inhibitory and anti-glycation activities in vitro and learning and memory function improvements in scopolamine-induced amnesiac mice

Chen, L. G., Lin, S. Y., Lee, Y. S., Wang, C. C. & Hou, W. C., 8月 2021, 於: Biomedicines. 9, 8, 1066.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

7 引文斯高帕斯（Scopus）

2020

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., 3月 2020, 於: Food and Function. 11, 3, p. 2328-2338 11 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

18 引文斯高帕斯（Scopus）

In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland

Lin, C. M., Lin, Y. T., Lee, T. L., Imtiyaz, Z., Hou, W. C. & Lee, M. H., 1月 2020, 於: Journal of Food and Drug Analysis. 28, 1, p. 147-158 12 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

23 引文斯高帕斯（Scopus）

Reductions of copper ion-mediated low-density lipoprotein (LDL) oxidations of trypsin inhibitors, the sweet potato root major proteins, and LDL binding capacities

Lu, Y. L., Lee, C. J., Lin, S. Y. & Hou, W. C., 12月 1 2020, 於: Botanical Studies. 61, 1, 26.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

3 引文斯高帕斯（Scopus）

2019

Anti-glycation, anti-hemolysis, and ORAC activities of demethylcurcumin and tetrahydroxycurcumin in vitro and reductions of oxidative stress in d-galactose-induced BALB/c mice in vivo

Liu, Y. H., Lee, T. L., Han, C. H., Lee, Y. S. & Hou, W. C., 12月 1 2019, 於: Botanical Studies. 60, 1, 9.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

10 引文斯高帕斯（Scopus）

2018

135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) to Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice

Wu, G. C., Lin, S. Y., Liang, H. J. & Hou, W. C., 1月 24 2018, 於: Journal of Agricultural and Food Chemistry. 66, 3, p. 645-652 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

8 引文斯高帕斯（Scopus）

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., 7月 3 2018, 於: Frontiers in Pharmacology. 9, JUL, 708.

研究成果: 雜誌貢獻 › 文章 › 同行評審

8 引文斯高帕斯（Scopus）

2017

Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro

Liu, Y. H., Lu, Y. L., Liu, D. Z. & Hou, W. C., 7月 13 2017, 於: Drug Design, Development and Therapy. 11, p. 2139-2147 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

7 引文斯高帕斯（Scopus）

Hot-Water Extracts from Roots of Vitis thunbergii var. taiwaniana and Identified ε-Viniferin Improve Obesity in High-Fat Diet-Induced Mice

Lu, Y. L., Lin, S. Y., Fang, S. U., Hsieh, Y. Y., Chen, C. R., Wen, C. L., Chang, C. I. & Hou, W. C., 3月 29 2017, 於: Journal of Agricultural and Food Chemistry. 65, 12, p. 2521-2529 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

15 引文斯高帕斯（Scopus）

2016

Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease

Chen, P. T., Chen, Z. T., Hou, W. C., Yu, L. C. & Chen, R. P. Y., 7月 13 2016, 於: Scientific Reports. 6, 29760.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

41 引文斯高帕斯（Scopus）

Protective Effects of Minor Components of Curcuminoids on Hydrogen Peroxide-Treated Human HaCaT Keratinocytes

Liu, Y. H., Lin, Y. S., Huang, Y. W., Fang, S. U., Lin, S. Y. & Hou, W. C., 5月 11 2016, 於: Journal of Agricultural and Food Chemistry. 64, 18, p. 3598-3608 11 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

25 引文斯高帕斯（Scopus）

Synthesized Peptides from Yam Dioscorin Hydrolysis in Silico Exhibit Dipeptidyl Peptidase-IV Inhibitory Activities and Oral Glucose Tolerance Improvements in Normal Mice

Lin, Y. S., Han, C. H., Lin, S. Y. & Hou, W. C., 8月 24 2016, 於: Journal of Agricultural and Food Chemistry. 64, 33, p. 6451-6458 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

28 引文斯高帕斯（Scopus）

2015

Anti-α-glucosidase and Anti-dipeptidyl Peptidase-IV Activities of Extracts and Purified Compounds from Vitis thunbergii var. taiwaniana

Lin, Y. S., Chen, C. R., Wu, W. H., Wen, C. L., Chang, C. I. & Hou, W. C., 7月 22 2015, 於: Journal of Agricultural and Food Chemistry. 63, 28, p. 6393-6401 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

50 引文斯高帕斯（Scopus）

Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo

Liu, Y.-H., Lin, Y.-S., Lin, K.-L., Lu, Y.-L., Chen, C.-H., Chien, M.-Y., Shang, H.-F., Lin, S.-Y. & Hou, W.-C., 2015, 於: Botanical Studies. 56, 1, p. 1-10 10 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

20 引文斯高帕斯（Scopus）

Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats

Shih, S.-L., Lin, Y.-S., Lin, S.-Y. & Hou, W.-C., 2015, 於: Botanical Studies. 56, 1, p. 1-9 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

17 引文斯高帕斯（Scopus）

Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

Lin, Y. S., Wu, W. C., Lin, S. Y. & Hou, W. C., 3月 2015, 於: Amino Acids. 47, 3, p. 617-625 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

14 引文斯高帕斯（Scopus）

Vitis thunbergii var. taiwaniana Extracts and Purified Compounds Ameliorate Obesity in High-Fat Diet-Induced Obese Mice

Lin, S. Y., Huang, G. C., Hsieh, Y. Y., Lin, Y. S., Han, C. H., Wen, C. L., Chang, C. I. & Hou, W. C., 10月 28 2015, 於: Journal of Agricultural and Food Chemistry. 63, 42, p. 9286-9294 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

9 引文斯高帕斯（Scopus）

2014

Antioxidant and antiglycation activities of the synthesised dipeptide, Asn-Trp, derived from computer-aided simulation of yam dioscorin hydrolysis and its analogue, Gln-Trp

Han, C. H., Lin, Y. S., Lin, S. Y. & Hou, W. C., 2014, 於: Food Chemistry. 147, p. 195-202 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

37 引文斯高帕斯（Scopus）

Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions in D-galactose-induced BALB/c mice

Han, C. H., Lin, Y. S., Lee, T. L., Liang, H. J. & Hou, W. C., 9月 2014, 於: Food and Function. 5, 9, p. 2228-2236 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

19 引文斯高帕斯（Scopus）

Effects of yam tuber protein, dioscorin, on attenuating oxidative status and learning dysfunction in d-galactose-induced BALB/c mice

Han, C. H., Lin, Y. F., Lin, Y. S., Lee, T. L., Huang, W. J., Lin, S. Y. & Hou, W. C., 3月 2014, 於: Food and Chemical Toxicology. 65, p. 356-363 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

36 引文斯高帕斯（Scopus）

Vasorelaxing and antihypertensive activities of synthesized peptides derived from computer-aided simulation of pepsin hydrolysis of yam dioscorin

Lin, Y. S., Lu, Y. L., Wang, G. J., Liang, H. J. & Hou, W. C., 6月 7 2014, 於: Botanical Studies. 55, 1, 49.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

10 引文斯高帕斯（Scopus）

2013

Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from antrodia camphorata on the inflammatory mediator expression in mice

Deng, J. S., Huang, S. S., Lin, T. H., Lee, M. M., Kuo, C. C., Sung, P. J., Hou, W. C., Huang, G. J. & Kuo, Y. H., 5月 29 2013, 於: Journal of Agricultural and Food Chemistry. 61, 21, p. 5064-5071 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

51 引文斯高帕斯（Scopus）

Antioxidant activities of the synthesized thiol-contained peptides derived from computer-aided pepsin hydrolysis of yam tuber storage protein, dioscorin

Han, C. H., Liu, J. C., Fang, S. U. & Hou, W. C., 6月 1 2013, 於: Food Chemistry. 138, 2-3, p. 923-930 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

38 引文斯高帕斯（Scopus）

Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima

Huang, S. S., Chiu, C. S., Lin, T. H., Lee, M. M., Lee, C. Y., Chang, S. J., Hou, W. C., Huang, G. J. & Deng, J. S., 5月 20 2013, 於: Journal of Ethnopharmacology. 147, 2, p. 395-405 11 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

81 引文斯高帕斯（Scopus）

Antioxidant and anti-inflammatory properties of taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds

Chiu, C. S., Deng, J. S., Chang, H. Y., Chen, Y. C., Lee, M. M., Hou, W. C., Lee, C. Y., Huang, S. S. & Huang, G. J., 2013, 於: Food Chemistry. 141, 2, p. 1087-1096 10 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

71 引文斯高帕斯（Scopus）

Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

Huang, G. J., Deng, J. S., Huang, S. S., Lee, C. Y., Hou, W. C., Wang, S. Y., Sung, P. J. & Kuo, Y. H., 2013, 於: Food Chemistry. 141, 3, p. 3020-3027 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

69 引文斯高帕斯（Scopus）

Inhibitory activities of acteoside, isoacteoside, and its structural constituents against protein glycation in vitro

Liu, Y. H., Lu, Y. L., Han, C. H. & Hou, W. C., 8月 19 2013, 於: Botanical Studies. 54, 1

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

20 引文斯高帕斯（Scopus）

2012

Anti-inflammatory activities of Cinnamomum cassia constituents in vitro and in vivo

Liao, J. C., Deng, J. S., Chiu, C. S., Hou, W. C., Huang, S. S., Shie, P. H. & Huang, G. J., 2012, 於: Evidence-based Complementary and Alternative Medicine. 2012, 429320.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

225 引文斯高帕斯（Scopus）

Antioxidant, antinociceptive, and anti-inflammatory activities from actinidia callosa var. callosa in vitro and in vivo

Liao, J. C., Deng, J. S., Lin, Y. C., Lee, C. Y., Lee, M. M., Hou, W. C., Huang, S. S. & Huang, G. J., 2012, 於: Evidence-based Complementary and Alternative Medicine. 2012, 129152.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

15 引文斯高帕斯（Scopus）

Antioxidant activities of different wild bitter gourd (Momordica charantia l. var. abbreviata seringe) cultivars

Lu, Y. L., Liu, Y. H., Chyuan, J. H., Cheng, K. T., Liang, W. L. & Hou, W. C., 4月 2012, 於: Botanical Studies. 53, 2, p. 207-214 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

28 引文斯高帕斯（Scopus）

Antioxidant and antihypertensive activities of acteoside and its analogs

Chen, C. H., Lin, Y. S., Chien, M. Y., Hou, W. C. & Hu, M. L., 10月 2012, 於: Botanical Studies. 53, 4, p. 421-429 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

22 引文斯高帕斯（Scopus）

Biological activities and applications of dioscorins,the major tuber storage proteins of yam

Lu, Y. L., Chia, C. Y., Liu, Y. W. & Hou, W. C., 2012, 於: Journal of Traditional and Complementary Medicine. 2, 1, p. 41-46 6 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

46 引文斯高帕斯（Scopus）

Characterization of a novel Cyclophilin-type peptidylprolyl isomerase protein from sweet potato storage roots

Liao, J. C., Chiu, C. S., Chen, H. J., Huang, S. S., Hou, W. C., Lin, W. C., Lin, Y. H. & Huang, G. J., 7月 2012, 於: Botanical Studies. 53, 3, p. 315-324 10 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

Chemical compositions, anti-inflammatory, antiproliferative and radical-scavenging activities of Actinidia callosa var. ephippioides

Liao, J. C., Deng, J. S., Chiu, C. S., Huang, S. S., Hou, W. C., Lin, W. C. & Huang, G. J., 2012, 於: American Journal of Chinese Medicine. 40, 5, p. 1047-1062 16 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

28 引文斯高帕斯（Scopus）

Defensin protein from sweet potato (Ipomoea batatas [L.] Lam 'Tainong 57') storage roots exhibits antioxidant activities in vitro and ex vivo

Huang, G. J., Deng, J. S., Chen, H. J., Huang, S. S., Liao, J. C., Hou, W. C. & Lin, Y. H., 12月 1 2012, 於: Food Chemistry. 135, 3, p. 861-867 7 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

17 引文斯高帕斯（Scopus）

Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells

Huang, C.-Y., Shih, C.-M., Tsao, N.-W., Lin, Y. W., Huang, P. H., Wu, S. C., Lee, A.-W., Kao, Y. T., Chang, N.-C., Nakagami, H., Morishita, R., Ou, K.-L., Hou, W.-C., Lin, C. Y., Shyu, K.-G. & Lin, F.-Y., 12月 2012, 於: British Journal of Pharmacology. 167, 7, p. 1506-1519 14 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

78 引文斯高帕斯（Scopus）

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S.-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., 6月 15 2012, 於: Food Chemistry. 132, 4, p. 2074-2080 7 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

39 引文斯高帕斯（Scopus）

Ethanolic extracts and isolated compounds from small-leaf grape (Vitis thunbergii var. taiwaniana) with antihypertensive activities

Lin, Y. S., Lu, Y. L., Wang, G. J., Chen, L. G., Wen, C. L. & Hou, W. C., 8月 1 2012, 於: Journal of Agricultural and Food Chemistry. 60, 30, p. 7435-7441 7 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

22 引文斯高帕斯（Scopus）

Evaluation of antioxidant and free radical scavenging capacities of polyphenolics from pods of caesalpinia pulcherrima

Hsu, F.-L., Huang, W. J., Wu, T. H., Lee, M. H., Chen, L. C., Lu, H. J., Hou, W. C. & Lin, M. H., 5月 2012, 於: International journal of molecular sciences. 13, 5, p. 6073-6088 16 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

41 引文斯高帕斯（Scopus）

Hepatoprotective effect of the ethanol extract of Vitis thunbergii on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities

Deng, J. S., Chang, Y. C., Wen, C. L., Liao, J. C., Hou, W. C., Amagaya, S., Huang, S. S. & Huang, G. J., 8月 1 2012, 於: Journal of Ethnopharmacology. 142, 3, p. 795-803 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

45 引文斯高帕斯（Scopus）

Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis

Huang, G. J., Deng, J. S., Liao, J. C., Hou, W. C., Wang, S. Y., Sung, P. J. & Kuo, Y. H., 2月 22 2012, 於: Journal of Agricultural and Food Chemistry. 60, 7, p. 1673-1681 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

112 引文斯高帕斯（Scopus）

侯 文琪

研究成果

搜尋結果

侯文琪