個人檔案
學歷
- 2014 國立成功大學生物資訊與訊息傳遞研究所博士
- 2009 國立成功大學生物資訊研究所碩士
- 2007 國立嘉義大學生物農業科技學系學士
經歷
- 2024.02- 臺北醫學大學神經醫學博士學位學程助理教授
- 2021.06- 臺北醫學大學神經醫學研究中心助理研究員
- 2017.04-2021.05 臺北醫學大學醫學科學研究所博士後研究員
- 2016.03-2017.03 國立交通大學生物科技學系博士後研究員
- 2015.03-2016.03 國家衛生研究院國家環境醫學研究所博士後研究員
獎項
- 2019.05 Exhibition of Excellent Poster by the 34th Joint Annual Conference of Biomedical Science
- 2013.11 Exhibition of Excellent Poster by the 3rd International Symposium on Infectious Disease and Signal Transduction
研究興趣
- 分子生物學
- 細胞生物學
- 癌症生物學
- 生物資訊學
- 大數據分析
其它
Skills
- Interdisciplinary Considerations (biomedicine and computational science).
- Design the experiment independently and do the troubleshooting with colleagues.
- Confidently report information and research findings in writing.
- Patent analysis and patent portfolio.
- Big Data analytics and bioinformatics: Single-cell analysis (including scATAC-seq and scRNA-seq) using Cell Ranger and R language (Seurat package), high-throughput sequence analysis (RNA-seq, DNA methylation and cDNA microarray) using CLC Genomics Workbench and R language, functional analysis using MetaCore and Ingenuity Pathway Analysis, writing and editing a C program, and constructing a local MySQL relational database.
- Drug discovery: Post processing of protein-compound docking for structure-based drug discovery and development, systemic approaches to identify potential targets and drugs for drug repositioning in several diseases.
- Biochemistry and Molecular Biology: Protein purification from coli, western blot, plasmid construction, isolation and purification of genomic DNA, mRNA and microRNA, real-time PCR, agarose gel electrophoresis, SNP technology, and yeast two-hybrid screening.
- Cell Biology: Cell-related assays techniques (such as cell culture), microscopy imaging techniques (using confocal and time-lapse microscopy), and flow cytometry.
- Animal model: Zebrafish model, xenograft, metastasis, TBI, and orthotopic GBM mice model.
- Proteomics: Desalting and Mass Spectrometry (LTQ Orbitrap LC-MS/MS system), including in-gel or in-solution protein digestion, purification, MS/MS analysis, and analysis of proteomics data.
指紋
- 1 類似的個人檔案
過去五年中的合作和熱門研究領域
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釐清γ-氨基丁酸介導的膠質母細胞瘤中與帝盟多抗藥性相關的表觀遺傳變化(2/3)
Yang, W.-B. (PI)
8/1/25 → 7/31/26
研究計畫: A - 政府部門 › b - 國家科學及技術委員會
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釐清γ-氨基丁酸介導的膠質母細胞瘤中與帝盟多抗藥性相關的表觀遺傳變化(1/3)
Yang, W.-B. (PI)
8/1/24 → 7/31/25
研究計畫: A - 政府部門 › b - 國家科學及技術委員會
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Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model
Chen, J. H., Chang, C. W., Chen, Y. Y., Yang, C. H., Yang, W. B., Hsieh, Y. C., Liang, Y. W., Li, S. J. & Hu, C. J., 3月 2026, 於: Alzheimer's and Dementia. 22, 3, e71290.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取 -
A novel dual CDC25-HDAC inhibitor suppresses glioblastoma progression via chromosomal passenger complex disruption
Upadhyay, R., Sethy, B., Yang, W. B., Wu, M. H., Liou, K. C., Wu, A. C., Narwanti, I., Nepali, K., Liou, J. P. & Chuang, J. Y., 12月 2025, 於: Biomedicine and Pharmacotherapy. 193, 118816.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取 -
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Mwale, P. F., Hsieh, C. T., Yen, T. L., Jan, J. S., Taliyan, R., Yang, C. H. & Yang, W. B., 12月 2025, 於: Molecular Neurodegeneration. 20, 1, 7.研究成果: 雜誌貢獻 › 回顧型文獻 › 同行評審
開啟存取31 連結會在新分頁中打開 引文 斯高帕斯（Scopus） -
Contribution of Prostaglandin E2-Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative
Shen, C. J., Chen, H. C., Lin, C. L., Thakur, A., Onuku, R., Chen, I. C., Li, H. Y., Chang, K. Y., Chuang, J. Y., Yang, W. B., Lin, H. Y., Shen, Y. R., Liou, J. P., Chang, W. C. & Hsu, T. I., 10月 13 2025, 於: Advanced Science. 12, 38, e06336.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取7 連結會在新分頁中打開 引文 斯高帕斯（Scopus） -
Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies
Chen, I. C., Lin, H. Y., Liu, Z. Y., Cheng, W. J., Yeh, T. Y., Yang, W. B., Tran, H. Y., Lai, M. J., Wang, C. H., Kao, T. Y., Hung, C. Y., Huang, Y. L., Liou, K. C., Hsieh, C. M., Hsu, T. I. & Liou, J. P., 2025, 於: Journal of Medicinal Chemistry. 68, 3, p. 2779-2803 25 p.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取7 連結會在新分頁中打開 引文 斯高帕斯（Scopus）
資料集
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Additional file 2 of Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
Young, M.-J. (Creator), Chen, Y.-C. (Creator), Wang, S.-A. (Creator), Chang, H.-P. (Creator), Yang, W.-B. (Creator), Lee, C.-C. (Creator), Liu, C.-Y. (Creator), Tseng, Y.-L. (Creator), Wang, Y.-C. (Creator), Sun, H. S. (Creator), Chang, W.-C. (Creator) & Hung, J.-J. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.18517662.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Estradiol-mediated_inhibition_of_Sp1_decreases_miR-3194-5p_expression_to_enhance_CD44_expression_during_lung_cancer_progression/18517662/1
資料集: Dataset
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MOESM4 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Lo, W.-L. (Creator), Chu, J.-M. (Contributor), Yang, K.-Y. (Creator), Liu, M.-S. (Creator), Liu, J.-J. (Creator), Chen, P.-Y. (Contributor), Chung, P.-H. (Contributor), Chuang, J.-Y. (Creator), Chien, C.-H. (Contributor), Chang, K.-Y. (Contributor), Yang, W.-B. (Creator), Huang, C.-Y. (Contributor), Yang, S.-T. (Creator), Chen, S.-H. (Contributor), Chou, S.-W. (Creator) & Hsu, T.-I. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006862.v1, https://doi.org/10.6084%2Fm9.figshare.10006862.v1
資料集: Dataset
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Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation
Tsai, Y.-T. (Creator), Lo, W.-L. (Creator), Chen, P.-Y. (Creator), Ko, C.-Y. (Creator), Chuang, J.-Y. (Creator), Kao, T.-J. (Creator), Yang, W.-B. (Creator), Chang, K.-Y. (Creator), Hung, C.-Y. (Creator), Kikkawa, U. (Creator), Chang, W.-C. (Creator) & Hsu, T.-I. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.c.5916320.v1, https://springernature.figshare.com/collections/Reprogramming_of_arachidonate_metabolism_confers_temozolomide_resistance_to_glioblastoma_through_enhancing_mitochondrial_activity_in_fatty_acid_oxidation/5916320/1
資料集: Dataset
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MOESM3 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Liu, J.-J. (Creator), Hsu, T.-I. (Contributor), Chou, S.-W. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Chen, P.-Y. (Contributor), Chen, S.-H. (Contributor), Yang, S.-T. (Creator), Chu, J.-M. (Contributor), Huang, C.-Y. (Contributor), Yang, K.-Y. (Creator), Chien, C.-H. (Contributor), Chung, P.-H. (Contributor), Lo, W.-L. (Creator), Liu, M.-S. (Creator) & Chang, K.-Y. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006856.v1, https://doi.org/10.6084%2Fm9.figshare.10006856.v1
資料集: Dataset
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MOESM8 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chung, P.-H. (Contributor), Chen, S.-H. (Contributor), Hsu, T.-I. (Contributor), Liu, M.-S. (Creator), Lo, W.-L. (Creator), Chu, J.-M. (Contributor), Yang, K.-Y. (Creator), Yang, S.-T. (Creator), Liu, J.-J. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Huang, C.-Y. (Contributor), Chien, C.-H. (Contributor), Chang, K.-Y. (Contributor), Chen, P.-Y. (Contributor) & Chou, S.-W. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006883.v1, https://doi.org/10.6084%2Fm9.figshare.10006883.v1
資料集: Dataset