每年專案
個人檔案
學歷
- 2014 國立成功大學生物資訊與訊息傳遞研究所博士
- 2009 國立成功大學生物資訊研究所碩士
- 2007 國立嘉義大學生物農業科技學系學士
經歷
- 2024.02- 臺北醫學大學神經醫學博士學位學程助理教授
- 2021.06- 臺北醫學大學神經醫學研究中心助理研究員
- 2017.04-2021.05 臺北醫學大學醫學科學研究所博士後研究員
- 2016.03-2017.03 國立交通大學生物科技學系博士後研究員
- 2015.03-2016.03 國家衛生研究院國家環境醫學研究所博士後研究員
獎項
- 2019.05 Exhibition of Excellent Poster by the 34th Joint Annual Conference of Biomedical Science
- 2013.11 Exhibition of Excellent Poster by the 3rd International Symposium on Infectious Disease and Signal Transduction
研究興趣
- 分子生物學
- 細胞生物學
- 癌症生物學
- 生物資訊學
- 大數據分析
其它
Skills
- Interdisciplinary Considerations (biomedicine and computational science).
- Design the experiment independently and do the troubleshooting with colleagues.
- Confidently report information and research findings in writing.
- Patent analysis and patent portfolio.
- Big Data analytics and bioinformatics: Single-cell analysis (including scATAC-seq and scRNA-seq) using Cell Ranger and R language (Seurat package), high-throughput sequence analysis (RNA-seq, DNA methylation and cDNA microarray) using CLC Genomics Workbench and R language, functional analysis using MetaCore and Ingenuity Pathway Analysis, writing and editing a C program, and constructing a local MySQL relational database.
- Drug discovery: Post processing of protein-compound docking for structure-based drug discovery and development, systemic approaches to identify potential targets and drugs for drug repositioning in several diseases.
- Biochemistry and Molecular Biology: Protein purification from coli, western blot, plasmid construction, isolation and purification of genomic DNA, mRNA and microRNA, real-time PCR, agarose gel electrophoresis, SNP technology, and yeast two-hybrid screening.
- Cell Biology: Cell-related assays techniques (such as cell culture), microscopy imaging techniques (using confocal and time-lapse microscopy), and flow cytometry.
- Animal model: Zebrafish model, xenograft, metastasis, TBI, and orthotopic GBM mice model.
- Proteomics: Desalting and Mass Spectrometry (LTQ Orbitrap LC-MS/MS system), including in-gel or in-solution protein digestion, purification, MS/MS analysis, and analysis of proteomics data.
指紋
查看啟用 Wen-Bin Yang 的研究主題。這些主題標籤來自此人的作品。共同形成了獨特的指紋。
- 1 類似的個人檔案
過去五年中的合作和熱門研究領域
國家/地區層面的近期外部共同作業。按一下圓點深入探索詳細資料，或
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釐清γ-氨基丁酸介導的膠質母細胞瘤中與帝盟多抗藥性相關的表觀遺傳變化(1/3)
Yang, W.-B. (PI)
8/1/24 → 7/31/25
研究計畫: A - 政府部門 › b - 國家科學及技術委員會
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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Mwale, P. F., Hsieh, C. T., Yen, T. L., Jan, J. S., Taliyan, R., Yang, C. H. & Yang, W. B., 12月 2025, 於: Molecular Neurodegeneration. 20, 1, 7.研究成果: 雜誌貢獻 › 回顧型文獻 › 同行評審
開啟存取1 引文 斯高帕斯（Scopus） -
Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies
Chen, I. C., Lin, H. Y., Liu, Z. Y., Cheng, W. J., Yeh, T. Y., Yang, W. B., Tran, H. Y., Lai, M. J., Wang, C. H., Kao, T. Y., Hung, C. Y., Huang, Y. L., Liou, K. C., Hsieh, C. M., Hsu, T. I. & Liou, J. P., 2025, 於: Journal of Medicinal Chemistry. 68, 3, p. 2779-2803 25 p.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取 -
CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
Liu, C. C., Yang, W. B., Chien, C. H., Wu, C. L., Chuang, J. Y., Chen, P. Y., Chu, J. M., Cheng, S. M., Qiu, L. Y., Chang, Y. C., Hwang, D. Y., Huang, C. Y., Lee, J. S. & Chang, K. Y., 6月 2024, 於: Cell Death and Disease. 15, 6, 434.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取3 引文 斯高帕斯（Scopus） -
Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress
Sharma, R., Chiang, Y. H., Chen, H. C., Lin, H. Y., Yang, W. B., Nepali, K., Lai, M. J., Chen, K. Y., Liou, J. P. & Hsu, T. I., 4月 1 2024, 於: Cancer Letters. 586, 216666.研究成果: 雜誌貢獻 › 文章 › 同行評審
5 引文 斯高帕斯（Scopus） -
First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitro and In Vivo
Sharma, S., Wang, S. A., Yang, W. B., Lin, H. Y., Lai, M. J., Chen, H. C., Kao, T. Y., Hsu, F. L., Nepali, K., Hsu, T. I. & Liou, J. P., 2月 22 2024, 於: Journal of Medicinal Chemistry. 67, 4, p. 2963-2985 23 p.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取4 引文 斯高帕斯（Scopus）
資料集
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MOESM3 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Liu, J.-J. (Creator), Hsu, T.-I. (Contributor), Chou, S.-W. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Chen, P.-Y. (Contributor), Chen, S.-H. (Contributor), Yang, S.-T. (Creator), Chu, J.-M. (Contributor), Huang, C.-Y. (Contributor), Yang, K.-Y. (Creator), Chien, C.-H. (Contributor), Chung, P.-H. (Contributor), Lo, W.-L. (Creator), Liu, M.-S. (Creator) & Chang, K.-Y. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006856.v1, https://doi.org/10.6084%2Fm9.figshare.10006856.v1
資料集: Dataset
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MOESM7 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chou, S.-W. (Creator), Chen, P.-Y. (Contributor), Chu, J.-M. (Contributor), Chien, C.-H. (Contributor), Liu, J.-J. (Creator), Liu, M.-S. (Creator), Chuang, J.-Y. (Creator), Chung, P.-H. (Contributor), Hsu, T.-I. (Contributor), Chen, S.-H. (Contributor), Yang, S.-T. (Creator), Lo, W.-L. (Creator), Huang, C.-Y. (Contributor), Chang, K.-Y. (Contributor), Yang, K.-Y. (Creator) & Yang, W.-B. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006880.v1, https://doi.org/10.6084%2Fm9.figshare.10006880.v1
資料集: Dataset
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MOESM2 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chen, P.-Y. (Contributor), Yang, W.-B. (Creator), Chou, S.-W. (Creator), Yang, S.-T. (Creator), Chung, P.-H. (Contributor), Chang, K.-Y. (Contributor), Liu, M.-S. (Creator), Chen, S.-H. (Contributor), Chien, C.-H. (Contributor), Hsu, T.-I. (Contributor), Chu, J.-M. (Contributor), Huang, C.-Y. (Contributor), Yang, K.-Y. (Creator), Liu, J.-J. (Creator), Chuang, J.-Y. (Creator) & Lo, W.-L. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006850.v1, https://doi.org/10.6084%2Fm9.figshare.10006850.v1
資料集: Dataset
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MOESM8 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chung, P.-H. (Contributor), Chen, S.-H. (Contributor), Hsu, T.-I. (Contributor), Liu, M.-S. (Creator), Lo, W.-L. (Creator), Chu, J.-M. (Contributor), Yang, K.-Y. (Creator), Yang, S.-T. (Creator), Liu, J.-J. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Huang, C.-Y. (Contributor), Chien, C.-H. (Contributor), Chang, K.-Y. (Contributor), Chen, P.-Y. (Contributor) & Chou, S.-W. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006883.v1, https://doi.org/10.6084%2Fm9.figshare.10006883.v1
資料集: Dataset
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Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chien, C.-H. (Contributor), Chuang, J.-Y. (Creator), Yang, S.-T. (Creator), Yang, W.-B. (Creator), Chen, P.-Y. (Contributor), Hsu, T.-I. (Contributor), Huang, C.-Y. (Contributor), Lo, W.-L. (Creator), Yang, K.-Y. (Creator), Liu, M.-S. (Creator), Chu, J.-M. (Contributor), Chung, P.-H. (Contributor), Liu, J.-J. (Creator), Chou, S.-W. (Creator), Chen, S.-H. (Contributor) & Chang, K.-Y. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.c.4705370.v1, https://doi.org/10.6084%2Fm9.figshare.c.4705370.v1
資料集: Dataset